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Synthesis of 14-imino-11-methyl-9, 13-dioxo-8H-pyrimido [1, 2-a] pyrimido [4, 5-d] pyrimido [2, 1-b] [1, 3] benzothiazole derivatives and evaluation of their biological activity

Author Affiliations

  • 1P.G. Research centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded -431602, MS, India

Res. J. Recent Sci., Volume 6, Issue (2), Pages 21-24, February,2 (2017)


The broad spectrum biological importance of sulphur and nitrogen containing heterocycles were constantly encouraged chemists to synthesize their large number of derivatives during last few decades. one of the most significant compound among these are benzothiazole derivatives which was found to be biologically and medicinally potent. in this study we condensed a mixture of 3-cyano-2-methylthio-6-methyl-4, 8-dioxo-9H-pyrimido [1, 2-a] pyrimidine and differently substituted benzothiazoles in the incidence of K2CO3 and DMSO as a reaction solvent, to get corresponding 14-imino-11-methyl-9, 13-dioxo-8H-pyrimido [1, 2-a] pyrimido - pyrimido [2, 1-b] [1, 3] benzothiazole derivatives. All the products were confirmed on the basis of IR, 1H NMR and mass spectroscopic techniques and evaluate their biological activity.


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