International Science Community Association Research Journal of Recent Sciences 2277 - 2502 6 2 2017 02 2 Synthesis of 14-imino-11-methyl-9, 13-dioxo-8H-pyrimido [1, 2-a] pyrimido [4, 5-d] pyrimido [2, 1-b] [1, 3] benzothiazole derivatives and evaluation of their biological activity 21 24 EN Khanna Lavanya 1 Department of Physics, Panjab University, Chandigarh-160014, India Tripathi S.K. 2 Department of Physics, Panjab University, Chandigarh-160014, India Sarkar Atreyi 1 Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata – 700032, India Ghosh Uma 2 Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata – 700032, India D. Tripathi 1 Shivoma Ashram, 83 Dwarkapuri, 20x40 Block Line, Indore, M.P., India Y. Kalantri 2 Shah Pathology, 410, Nandlalpura Chouraha, Jawahar Marg, Indore, M.P., India H. Kumar 3 Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA V. Chitnis 4 CHL Hospital, Department of Microbiology, AB Road, Near LIG Square, Indore, M.P., India S. Chitnis 5 CHL Hospital, Department of Microbiology, AB Road, Near LIG Square, Indore, M.P., India R.C. Kalantri 6 Kalantri Nursing Home, 219, Jawahar Marg, Indore, M.P., India J.K. Bhatt 7 Shivoma Ashram, 83 Dwarkapuri, 20x40 Block Line, Indore, M.P., India Sontakke Sandeep G. 1 P.G. Research centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded -431602, MS, India > Research Paper 2016 11 30 2017 02 2 The broad spectrum biological importance of sulphur and nitrogen containing heterocycles were constantly encouraged chemists to synthesize their large number of derivatives during last few decades. one of the most significant compound among these are benzothiazole derivatives which was found to be biologically and medicinally potent. in this study we condensed a mixture of 3-cyano-2-methylthio-6-methyl-4, 8-dioxo-9H-pyrimido [1, 2-a] pyrimidine and differently substituted benzothiazoles in the incidence of K2CO3 and DMSO as a reaction solvent, to get corresponding 14-imino-11-methyl-9, 13-dioxo-8H-pyrimido [1, 2-a] pyrimido - pyrimido [2, 1-b] [1, 3] benzothiazole derivatives. All the products were confirmed on the basis of IR, 1H NMR and mass spectroscopic techniques and evaluate their biological activity. Copyright@ International Science Community Association