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Synthesis, Spectral Sharacterization and Antimicrobial Studies of Ni(II), Co(II) and Mn(II) Complexes with Schiff Base Ligand derived from 3,5-Dibromosalicylaldehyde

Author Affiliations

  • 1Department of Chemistry, Shivaji, Art’s, Comm. & Science College Kannad. Dist. Chhatrapti Sambhajinagar-431103, MS, India

Res.J.chem.sci., Volume 16, Issue (2), Pages 21-29, June,18 (2026)

Abstract

A novel Schiff base ligand was created by combining 2-amino-4-chloro-6-methylpyrimidine with 3,5-Dibromosalicylaldehyde through a condensation reaction. Metal complexes were formed by reacting the Schiff base with Iron nitrate in an ethanol solution. These complexes were then collected, cleaned, and dried. The Schiff base appears pale yellow, while the complexes with Ni(II), Co(II), and Mn(II) exhibit a light yellow color. Characterization of the synthesized compounds was performed using FT-IR, 1H-NMR, and UV-Vis methods for the ligands, along with FT-IR and UV-Vis for the complexes, as well as assessing all reactions via TLC, molar conductivity, and magnetic susceptibility measurements. The complexes exhibit paramagnetic properties. Molar conductivity assessments showed that all the complexes act as non-electrolytes when dissolved in DMSO. An octahedral structure was determined for all complexes. The ligands function as bidentate (L) through their phenolic (OH) group and azomethine nitrogen. Both the ligand and its complexes were tested for antifungal and antibacterial effects against different strains, including Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme, Aspergillus flavus, and Escherichia coli, Salmonella typhi, Staphylococcus aureus,B. subtilis. The findings reveal that the complexes demonstrated significant antifungal and antibacterial activity.

References

  1. Sakhare D.T. (2025)., Synthesis, Spectroscopic Characterization and Antibacterial Investigation of Co(II), Fe(III), and Mn(II) Complexes with Schiff Base Ligand Derived from Substituted Aminopyrimidine., International Journal of Scientific Research in Chemistry, 10(5), 38-47.
  2. Sakhare, D. T. (2022)., Synthesis, Characterization and Antimicrobial Activity of Schiff Base Derived from 2-Hydroxybenzaldehyde with 2-Amino-4,6-Dimethylpyrimidine and their transition metal Complexes., GIS Science Journal, 9(4), 82-94.
  3. Sakhare, D.T. (2025),, Synthesis, Characterization and Antimicrobial Activities of Aminopyrimidine Schiff Base Ligand and their Complexes of Cu(II) and Mn(II)., Nigerian Research Journal of Chemical Sciences, 13,(1), 18-31.
  4. Sakhare, D.T. (2015)., Synthesis, characterization and antimicrobial activities of some Mn(II) and Fe(III) complexes of biologically active bidentate ligands, Journal of Chemical and Pharmaceutical Research, 7(6), 198-204.
  5. Sakhare, D.T.(2022)., Copper Metal Complexes of a Pyrimidine Based Schiff Base Ligand Synthesis, Characterization and Biological Activity., Journal of Xidian University, 16(3), 191-201.
  6. Sakhare, D.T. (2025)., Green Synthesis, Characterization and Biological Evaluation of Divalent Transition Metal Complexes of Substituted Aminopyrimidine Novel Schiff Base Ligand., Science Journal of Chemistry, 13(1), 1-10.
  7. Sakhare, D. T. (2022)., Synthesis, Characterization and biological Studies of Aminopyrimidine Schiff Bases and their Transition Metal Complexes., Dickensian Journal, 22(4),65-77.
  8. Sakhare, D.T. (2015)., Synthesis, Characterization of Some Transition Metal Complexes of Bidentate Schiff Base And their Antifungal and Antimicrobial Studies., Advances in Applied Science Research, 6(6),10-16.
  9. Sakhare, D. T. (2024)., Synthesis, characterization and biological activities of new bidentate Schiff base ligand and their Co (II) metal complexes., Materials Today: Proceedings, online.
  10. Sakhare, D.T. (2023)., Synthesis, Characterization And In-Vitro Biological Activities of Novel Bidentate Schiff Base Ligand and their Cobalt (II) Complexes., Juni Khyat, 13(07), No.03, 134-143.
  11. Sakhare, D.T. (2022)., Synthesis, Characterization and Antimicrobial Activity of Cu(II) Complexes Derived from Heterocyclic Schiff Bases Ligands., Asian Journal of Organic & Medicinal Chemistry, 7(2),41-47.
  12. Sakhare D. T. (2024)., Synthesis, Characterization And Biological Activity of New Schiff Bases 1-(((4,6-Dimethylpyrimidin-2-Yl)Imino)Methyl)Naphthalen-2-ol And Their Fe (III) Complexes., Juni Khyat, 14, 9(2), 101-111.
  13. Mohamed, G. G., Omar, M. M., & Hindy, A. M. (2005). Synthesis, characterization and biological activity of some transition metals with Schiff base derived from 2-thiophene carboxaldehyde and aminobenzoic acid. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 62(4-5), 1140-1150., undefined, undefined
  14. Sakhare, D.T. (2022)., Synthesis, Characterization and Antimicrobial Activity of Cu(II) Complexes Derived from Heterocyclic Schiff Bases Ligands., Asian Journal of Organic & Medicinal Chemistry, 7(2),41-47.
  15. Raman, N. Thalamuthu, S. J. Dhaveethuraja, M.A. Neelakandan and Banerjee, S.J. (2008)., Chil. Chem. Soc., 53, 21.
  16. Baraldi, P. G., Pavani, M. G., del Carmen Nunez, M., Brigidi, P., Vitali, B., Gambari, R., & Romagnoli, R. (2002)., Antimicrobial and antitumor activity of N-heteroimmine-1, 2, 3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines., Bioorganic & medicinal chemistry, 10(2), 449-456.
  17. Sakhare, D.T. (2015)., Synthesis, Spectral, Thermal And Antimicrobial Activities of Mn (II) And Fe (III) Schiff Base Metal Complexes., International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 2(7), 1-8.
  18. Sondhi, S. M., Johar, M., Rajvanshi, S., Dastidar, S. G., Shukla, R., Raghubir, R., & Lown, J. W. (2001)., Anticancer, anti-inflammatory and analgesic activity evaluation of heterocyclic compounds synthesized by the reaction of 4-isothiocyanato-4-methylpentan-2-one with substituted o-phenylenediamines, o-diaminopyridine and (un) substituted., Australian Journal of Chemistry, 54(1), 69-74.
  19. Sakhare, D.T. (2016)., Synthesis, Characterization of some Cu (ii) complexes of bidentate Schiff base and their antimicrobial studies., Journal of Medicinal Chemistry and Drug Discovery, 2(1), 583-597.
  20. Mangalagiu, G., Ungureanu, M., Grosu, G., Mangalagiu, I., & Petrovanu, M. (2001)., New pyrrolo-pyrimidine derivatives with antifungal or antibacterial properties in vitro., In Annales pharmaceutiques françaises (Vol. 59, No. 2, pp. 139-140).
  21. Sonmeza, M. Elebib, M.G. Leventb, A. Berberc, I. Enturkb, Z.S. (2010)., Journal of Coord. Chem., 63, 1986.
  22. Sakhare, D.T. (2025)., Green Synthesis, Characterization and Biological Investigation of Cr (II), Cu (II), and Fe (III) Complexes with Schiff Base Ligand Derived from Substituted Salicylaldehyde., Journal of Chemistry & its Applications, 2025,4(5), 1-7.
  23. Osowole1 A A, Kempe R, Schobert R and Balogun S. A.(2010). Candian journal of pure and applied sciences 4(2), 1169-1178., undefined, undefined
  24. Sakhare, D.T. (2015)., Syntheses, characterization of some transition metal complexes of bidentate schiff base and their antimicrobial activities., Der Chemica Sinica, 6(6):1-6.
  25. Osowole, A. A., & Akpan, E. J. (2012). Synthesis spectroscopic characterisation, in-vitro anticancer and antimicrobial activities of some metal (II) complexes of 3-{4, 6-dimethoxy pyrimidinyl) iminomethyl naphthalen-2-ol. Eur. J. Appl. Sci, 4, 14-20., undefined, undefined
  26. SM, I. (2018). Synthesis, Characterization And Antimicrobial Studies On Schiff Base Derived From 2-Aminopyridine And 2-Methoxybenzaldehyde And Its Cobalt (Ii) And Nickel (Ii) Complexes. Bayero Journal of Pure & Applied Sciences, 11., undefined, undefined
  27. Singh, V. and Singh, U. (2013)., Synthesis and Spectroscopic Studies of Schiff Base and Its Divalent and Trivalent Metal Complexes., Asian Journal of Chemistry, 2013; 25 (14):8195-8198.
  28. Sakhare, D.T. (2024)., Synthesis, Characterization and Biological Evaluation of Schiff Base Ligand and their Fe (III) Complexes., International Journal of Advanced Science and Engineering, 11(1), 3788-3797.
  29. Osowole, A. A., & Yoade, R. O. (2015). Synthesis, characterization and antibacterial studies on some metal (ii) complexes of 4-amino-6-hydroxy-2-mercaptopyrimidine. specialty journal of biological sciences, 1(1-2015), 1-6., undefined, undefined
  30. Sakhare, D.T. (2024)., Synthesis, Characterization And Spectroscopic Study of New 3-{[(4,6-Dihydroxy Pyrimidin-2-yl) imino]methyl}Napthalen-2-ol Schiff-Base LigandAnd It’s Transition Metal Complexes., International Journal of Scientific Research in Chemical Sciences , 11(1), 3788-3797.
  31. Usharani, M. Akila, E. And Rajavel, R. (2013)., Evaluation of the pharmacological proper Co (II), Cu(II), Ni (II) and Zn(II) complexes derived from 2-((e))-4-nitrophenylimino)methyl) phenol., International Journal of Recent Scientific Research, 4(9),1385- 1390.
  32. Sakhare, D.T. (2015)., Synthesis, Characterization And Antimicrobial Studies of Some Transition Metal Complexes of Schiff Bases., International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 2(6), 28–34.
  33. Avaji P. G., Reddy B. N. & Patil S. A., (2006).Synthesis, spectral characterization, biological and fluorescence studies of lanthanum(III) complexes with 3-substituted-4-amino-5-hydrazino-1,2,4-triazole Schiff bases, Transition Metal Chemistry, 31, 842-848., undefined, undefined
  34. Pargathi M. and Reddy K. H., Pargathi M. and Reddy K. H., (2013)., Synthesis, spectral characterization and DNA interactions of copper (II) and nickel (II) complexes with unsymmetrical Schiff base ligands., Indian Journal of Chemistry, 52A, 845-853.
  35. Sakhare, D.T. (2022)., Synthesis, Characterization and Biological Activity of New Schiff Bases Derived from Aminopyrimidine and Their Metal Complexes., International Journal of Scientific Research in Science and Technology, 9(17), 160-173.
  36. Sakhare, D.T. (2019)., Synthesis, characterization and in-vitro biological activities of Co (II) complexes of 2-(4-Methaylbenzylideneamino) Pyrimidine-4, 6-Diol.., Current Pharma Research, 9(4), 3335-3344.
  37. Despande, V. G., Shaha, S., Despande, M. M., Habib, S. I., & Kulkarni, P. A. (2013)., Synthesis spectroscopic characterization and biological activity of substituted aminopyrimidine Schiff base ligand and their metal complexes., Asian J Biochem Pharm Res, 1(3), 63-70.
  38. Sakhare, D.T. (2024)., Synthesis, Characterization and Antimicrobial Activity of Novel 2-Amino-4, 6- Dimethylpyrimidine and 2- Hydroxy-5- Nitrobenzaldehyde Schiff Base Ligand and Their Transition Metal Complexes., International Journal of Advance and Applied Research, 5(40), 35-44.
  39. Sakhare, D.T. (2025)., Synthesis, Characterization and Antimicrobial Activities of Aminopyrimidine Schiff Base Ligand and their Complexes of Cu(II) and Mn(II)., Nigerian Research Journal of Chemical Sciences, 13,(1), 18-31.
  40. Sakhare, D.T. (2015)., Synthesis, characterization and antimicrobial activities of some transition metal complexes of biologically active bidentate ligands., Inorganic Chemistry an Indian Journal, 10(4), 142-147.
  41. Sakhare, D.T. (2015)., Synthesis, characterization of some transition metal complexes of bidentate Schiff base and their antifungal and antimicrobial studies., Advances in Applied Science Research, 6(6), 10-16.