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Analysis of Glutathione S-Transferase Pi (GSTP1) Expression in Non Melanoma Skin Cancer using Bioinformatic Tools

Author Affiliations

  • 1 Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Gautam Budha Nagar, INDIA

Res. J. Recent Sci., Volume 4, Issue (IYSC-2015), Pages 40-47, September,2 (2015)


A bioinformatics study was carried out to study the expression of GSTP1 in non melanoma skin cancer (actinic keratosis and squamous cell carcinoma) by selecting non melanoma skin cancer research (record number GDS 2200) from the NCBI site. The experiment was analyzed using GEO data set and expression of GSTP1 in both control and actinic keratotic (AK) lesion, and squamous cell carcinoma (SCC) tumor biopsies data from 5 patients with non-melanoma skin cancer (NMSC) were analyzed. Known interactions for GSTP1 and coexpressed genes were also carried out using STRING database. The result shows that GSTP1 was over-expressed in the non melanoma samples (actinic keratosis and squamous cell carcinoma) compare with the control. Although one sample in the actinic keratosis shows higher expression, all the samples in squamous cell carcinoma show high expression of GSTP1. Result from STRING data base show that GSTP1interact and co-expressed with a number of genes which are important in understanding of cancer and progression of the disease. From the data generated, we concluded that GSTP1 was over-expressed in non melanoma skin cancer.


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