International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN. 

Numerical Simulation of Time-Dependent Electro-osmotic Micro-Mixer for Laboratory-On-a-Chip Applications

    , , ,

Author Affiliations

  • 1Department of Electrical Engineering, Ahar branch, Islamic Azad University, Ahar, IRAN

Res. J. Recent Sci., Volume 4, Issue (2), Pages 83-90, February,2 (2015)

Abstract

Design of Laboratory-On-a-Chip (LOC) devices and components such as micro-pump, micro-mixer, micro-separator, and micro-needle are main challenges in chemical and biological micro-engineering process. Due to low Reynolds number in micro-channel we need to perturb the fluid by time-dependent secondary lateral force. In this paper we design a novel miniaturized micro-channel with embedded electrodes in both micro-chamber and micro-channel. Efficient electro-osmotic flows are generated near the electrodes by exciting the electrodes properly. We studied the interaction between the fluids behavior, electric field and convection-diffusion equation in the proposed model. Velocity field and concentration analysis revealed a high performance mixing efficiency (above 96%) for a 130µm long mixer. The exciting parameters such as frequency and voltage effect are discussed to optimize the proposed micro-mixer.

References

  1. Alam A. Eman, Initiation of Pharmaceutical Factories depending on more Application of Biotechnology on some Medicinal Plants Review Article, 1(ISC-2011), Res. J. Recent Sci., 398-404 (2012)
  2. Mussarat Y., Muhammad S. and Sajjad Mohsin., Survey Paper on Diagnosis of Breast Cancer Using Image Processing Techniques, Res. J. Recent Sci., 2(10), 88-98 (2013)
  3. Raeisi Fard H., Nikkhah Bahrami M. and Yousefi-Koma A., Nonlinear Analysis and Mechanical Characterization of a Micro-Switch under Piezoelectric Actuation, Res. J. Recent Sci., 2(11), 35-41 (2013)
  4. Chauhan Rajsinh B. and Thundil Karuppa Raj R., Numerical Investigation of External Flow around the Ahmed Reference Body Using Computational Fluid Dynamics, Res. J. Recent Sci., 1(9), 1-5 (2012)
  5. Squires T.M. and Quake S.R., Microfluidics: Fluid physics at the nanoliter scale, Reviews of modern physics, 77, 977 (2005)
  6. He B., Burke B.J., Zhang X., Zhang R. and Regnier F.E., A picoliter-volume mixer for microfluidic analytical systems, Anal. Chem., 73, 1942-1947 (2001)
  7. Wang H., Iovenitti P., Harvey E. and Masood S., Optimizing layout of obstacles for enhanced mixing in microchannels, Smart materials and structures, 11, 662 (2002)
  8. Yang Z., Matsumoto S., Goto H., Matsumoto M. and Maeda R., Ultrasonic micromixer for microfluidic systems, Sensors and Actuators A: Physic., 93, 266-272 (2001)
  9. Oddy M., Santiago J. and Mikkelsen J., Electrokinetic instability micromixing, Anal. Chem., 73, 5822-5832, (2001)
  10. Morgan H. and Green N.G., AC electrokinetics: Colloids and nanoparticles. Research Study Press LTD, Baldock, Hertfordshire, England, (2003)
  11. Chen H., Zhang Y., Mezic I., Meinhart C. and Petzold L., Numerical simulation of an electroosmotic micromixer, Proceedings of International Mechanical Engineering Congress and Exposition, November 15-21, Washington D. C, USA, (2003)
  12. Mehdipour M., Vafaie R.H., Pourmand A., Poorreza E. and Ghavifekr H.B., A novel four phase AC electroosmotic micropump for lab-on-a-chip applications, in Proceedings of the 8th International Symposium on Mechatronics and its Applications (ISMA12, 2012), Sharjah, UAE, 10-12 April, (2012)
  13. Chang C. and Yang R.J., Computational analysis of electrokinetically driven flow mixing in microchannels with patterned blocks, Journal of Micromechanics and Microengineering, 14, 550 (2004)
  14. Probstein R.F., Physicochemical hydrodynamics, 833 : Wiley Online Library, (1994)
  15. Wu Z. and Micromixing D. Li, using induced-charge electrokinetic flow, Electrochimica Acta, 53, 5827-5835, (2008)
  16. Chen J. K. and Yang R. J., Electroosmotic flow mixing in zigzag microchannels, Electrophoresis., 28, 975-983, (2007)
  17. Ajdari A., Pumping liquids using asymmetric electrode arrays, Physical Review E, 61, 45-48 (2000)
  18. Kumar K. and Aggarwal M.L., A Finite Element Approach for Analysis of a Multi Leaf Spring using CAE Tools Res. J. Recent Sci., 1(2), 92-96, (2012)
  19. Thundil Karuppa, Raj R. and Ramsai R., Numerical study of fluid flow and effect of inlet pipe angle In catalytic converter using CFD, Res. J. Recent Sci., 1(7), 39-44 (2012)
  20. Vafaie R. H., Mehdipoor M., Pourmand A. and Badri H., An Electroosmotically-driven Micromixer modified for high Miniaturized Microchannels using Surface Micromachining, Biotechnology and Bioprocess Engineering, 18, 594-605, April (2013)
  21. Ottino J.M., The kinematics of mixing: stretching, chaos, and transport, Cambridge Univ Pr, , (1989)
  22. Erickson D. and Li D., Influence of surface heterogeneity on electrokinetically driven microfluidic mixing, Langmuir, 18, 1883-1892 (2002)
  23. Koch M., Witt H., Evans A. and Brunnschweiler A., Improved characterization technique for micromixers, Journal of Micromechanics and Microengineering 9, 156, (1999)
  24. Biddiss E., Erickson D. and Li D., Heterogeneous surface charge enhanced micromixing for electrokinetic flows, Analytical chemistry, 76, 3208-3213 (2004)
  25. Deval J., Tabeling P. and Ho C.M., A dielectrophoretic chaotic mixer Proc. MEMS’02, 15th IEEE Int. Workshop Micro Electromechanical System (Las Vegas, Nevada), 36–9, (2002)