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Synthesis of 3-Methyl-4-arylmethylene-isoxazol-5(4H)-ones catalyzed by Tartaric acid in aqueous media

Author Affiliations

  • 1Department of Chemistry, J. E. S. College, Jalna, MS, INDIA
  • 2Department of Chemistry, Dr. B.A.M.University, Aurangabad, MS, INDIA

Res.J.chem.sci., Volume 5, Issue (5), Pages 27-32, May,18 (2015)


An efficient and green synthesis of 3-Methyl-4-arylmethylene-isoxazol-5(4H)-ones using tartaric acid as a catalyst for the reaction of aromatic aldehydes, ethylacetoacetate and hydroxylamine hydrochloride in water as solvent is described. This protocol offers several advantages such as atom efficiency, short reaction time, easy work-up and simple reaction condition.


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