Synthesis, Characterization and Antimicrobial activity of some novel schiff Base 3d Transition Metal Complexes Derived from Dihydropyrimidinone and 4- Aminoantipyrine
Author Affiliations
- 1Sriram Engineering College, Department of chemistry, Perumalpattu, Chennai-602024, Tamil Nadu, INDIA
- 2PG and Research Department of Chemistry, Presidency College, Chennai–600 005, Tamil Nadu, INDIA
Res.J.chem.sci., Volume 4, Issue (7), Pages 11-17, July,18 (2014)
Abstract
Novel Schiff base and its 3d transition metal complexes of Mn(II), Fe(III) and VO(IV) has been designed and synthesized form 4-aminoantipyrine and Ethyl 4- methyl –oxo-6-phenylhexahyro pyrimidine-5-carboxylate . The ligand and complexes were characterized by physico chemical studies like solubility, melting point, elemental analysis, magnetic susceptibility, conductivity, and spectral studies like IR, UV/VIS spectra. From the data it has been observed that the complexes has the composition of ML2 type and paramagnetic nature, the complexes were coordinated through azomethine nitrogen and pyrazole oxygen of the ligand which was further supported by the appearance of new bands in IR spectra due to v (M-N) v(M-O) and v(M-Cl) .The ligand and its complexes had been screened for their antifungal and antibacterial activities against the fungi(Aspergillusniger ,Candida), and the bacteria (E.coli, Salmonella typhi Bacillus subtilis Staphylococcus aureus,) and showed good antimicrobial activities against the tested bacteria and fungi at 1000,750 and 500 mg/ml. Therefore possible use of the complexes as antibiotic can be suggested.
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