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Synthesis, Characterization and Antibacterial Activity and DNA cleavage Studies of tetra dentate Schiff bases and their Zn (II) Complexes

Author Affiliations

  • 1 Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, INDIA
  • 2 Department of Chemistry, Nizam College, Osmania University, Hyderabad, Andhra Pradesh, INDIA

Res.J.chem.sci., Volume 4, Issue (6), Pages 66-72, June,18 (2014)


A new series of tetra dentate Schiff base ligands are obtained from condensation of phthalaldehyde and 2-amino benzyl alcohol, 2-amino-2-methyl-1-propanol and 2-aminobenzo hydrazine respectively, L1-L3 were reacted with Zinc acetate in aqueous methanol to give Zinc complexes (4a-c). The synthesized ligands and complexes are characterized by elemental analysis, IR, 1H-NMR,Mass, Electronic spectra and molar conductance studies. All the complexes and ligands are examined for their anti-bacterial activitiesby cup plate method and their very low inhibitory concentration values verified by liquid dilution method. The DNA cleavage ability of the compounds was screened by agarose gel electrophoresis using calf thymus DNA(CT-DNA).The metal complexes are exhibited good anti-bacterial and DNA cleavage activities compared with their corresponding Schiff base ligands.


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