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Synthesis, Characterization and 1, 3-Dipolar Cycloaddition of Novel Sugar-Derived Nitrones with N-Arylmaleimides

Author Affiliations

  • 1Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore, Karnataka, INDIA
  • 2Department of Chemistry, College of health medical technology, Baghdad, IRAQ
  • 3Department of Chemistry, College of Science and Education University of Aden, YEMEN

Res.J.chem.sci., Volume 4, Issue (3), Pages 60-67, March,18 (2014)


The chiral N-D-ribosylnitrones 5-10 have been synthesized in four steps respectively, in the fourth step, D-ribosyloxime (4) condensed with substituted benzaldehyde in cool condition. The heterocyclization of Z- nitrone 6 with substituted N-arylmaleimide by 1,3-dipolar cycloaddition were afforded new heterocyclic system of isoxazolidine derivatives 11-16 and 11'-16' as a mixture of diastereoisomers, the new isoxazolidines 11-16 have been separated purely and characterized by H NMR, mass spectra and elemental analysis.


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