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DABCO Promoted Multi-Component one-pot Synthesis of Xanthene Derivatives

Author Affiliations

  • 1Laboratory of Heterocycles, School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain-456010, INDIA

Res.J.chem.sci., Volume 2, Issue (8), Pages 21-25, August,18 (2012)


The reaction of dimedone with various heteroaryl aldehydes afforded the corresponding heteroaryl substituted xanthene derivatives. Reaction proceeds via initial Knoevenagel, subsequent micheal and final heterocyclization reactions using 1,4-diazabicyclo(2.2.2)octane (DABCO) as catalyst. Short reaction time, environmentally friendly procedure, no need to use cumbersome apparatus for the purification of the products and excellent yields are the main advantages of this procedure which makes it more economic than the other conventional methods.


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