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Design and Investigations of Fluconazole Nanoparticles Doped Poly (vinyl alcohol) Composite Films for Food Packaging Uses

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Author Affiliations

  • 1Department of Industrial Chemistry, Mangalore University, Mangalagangothri, Mangalore-574199,State, Karnataka, India
  • 2Department of Industrial Chemistry, Mangalore University, Mangalagangothri, Mangalore-574199,State, Karnataka, India
  • 3Department of Chemistry, KLEs S. Nijalingappa College, Rajajinagar, 2nd Block Bangalore 560010, State Karnataka, India
  • 4Department of Studies in Biotechnology and Microbiology, Karnataka University, Dharwad-580003.State, Karnataka, India
  • 5Department of Industrial Chemistry, Mangalore University, Mangalagangotri, Mangalore-574199,State, Karnataka, India
  • 6Department of Industrial Chemistry, Mangalore University, Mangalagangotri, Mangalore-574199,State, Karnataka, India
  • 7Department of Chemistry, Karnataka University, Dharwad-580003.State, Karnataka, India
  • 8Department of Chemistry, Karnataka Science College, Dharwad - 580001. State, Karnataka, India

Res.J.chem.sci., Volume 16, Issue (1), Pages 63-73, February,18 (2026)

Abstract

Integrating functional agents into food packaging can prolong the serviceable life of products while preserving their standard and condition, also enhancing their attractiveness. The polyvinyl alcohol (PFLNPs) composite films that were used in the synthesis of fluconazole nanoparticles (PFLNPs) were produced by the solvent casting technique. The produced PVA and PFLNP composite films were characterized to examine morphology, mechanical properties, hydrophilicity, and antimicrobial characteristics utilizing UV, FT-IR, XRD, SEM, UTM, WCA, and antimicrobial assays. The study's findings indicated that the consistent integration of PFLNPs into the PVA matrix for food packaging applications resulted in improved crystallinity, enhanced intermolecular interactions, mechanical properties (Ts increased from 28.25 to 69.04, Ym from 16.21 to 3719 MPa, and a decrease in %Eb from 187 to 6.70), reduced hydrophilicity (from 62.82° to 76.58°), and a smooth, homogeneous morphology. The findings from the XRD analysis indicated a rise in crystallinity corresponding to the increased concentration of PFLNPs. The antimicrobial analysis revealed encouraging antimicrobial activities in opposition to both Gram-positive and Gram-negative bacteria. The findings of this study indicated that the composite films composed of the specified PFLNPs exhibited improved mechanical and antibacterial properties, potentially benefiting the pharmaceutical and food sectors.

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