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Synthesis, Structural elucidation, Pharmacological evaluation of Metal complexes with 2-Pyrazoline derivatives and Metalation effect on the Antimicrobial activity

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Author Affiliations

  • 1Department of Chemistry, Govt. Meera Girls College, MLSU Udaipur, Rajasthan, India
  • 2Department of Chemistry, Govt. Meera Girls College, MLSU Udaipur, Rajasthan, India

Res.J.chem.sci., Volume 15, Issue (1), Pages 25-28, February,18 (2025)

Abstract

1-Acetyl-5-(4-chlorophenyl/4-nitrophenyl)-3-(4-aminophenyl)-2-pyrazolines and their metal complexes have been synthesized and are being characterized through molecular weight determination, molar conductance, magnetic susceptibility, and spectroscopic techniques. The IR data have indicated that the coordination of ligands with the metal ions (Fe²⁺, Co²⁺, and Ni²⁺) occurs via azomethine nitrogen and carbonyl oxygen atoms. Microanalytical data, along with electronic spectral analysis and magnetic moment studies, suggested an octahedral geometry around the metal ions with a 1:2 metal-ligand ratio. Additionally, the complexes demonstrated significantly enhanced in vitro antimicrobial activity compared to the free ligand. The anti-microbial activities of these derivatives have been studied by screening them against bacteria such as Bacillus subtilis, Staphylococcus aureus, and Escherichia coli and fungi such as Penicillium chrysogenum and Aspergillus niger by the Agar Well Diffusion method.

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