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New Biologically Active Compounds from 1,3-Diketones

Author Affiliations

  • 1Department of Chemistry, Gulu University, P.O. Box 166, Gulu, UGANDA
  • 2Department of Chemistry, Makerere University, P.O. Box 7062, Kampala, UGANDA Department of Paediatrics, Faculty of Medicine, Gulu University, P.O. Box 166, Gulu, UGANDA

Res.J.chem.sci., Volume 1, Issue (3), Pages 102-108, June,18 (2011)


The ready availability of cyclohexanones and the enhanced reactivity at their -positions render them starting materials of choice in the present study. The synthesis of new compounds of antimicrobial activity was undertaken by the coupling of aromatic amines with 5,5-dimethyl cyclohexan-1,3-dione (dimedone). The products were refluxed with N–benzyl-N-phenylhydrazine in acetic acid. The structures of the products were elucidated using micro- and IR-spectral analyses. They were confirmed using H NMR at 60MHz and TMS as internal standard. The diketone derivatives were tested for their biological activity against gram-positive Cocci and Bacilli, and gram-negative Bacilli. The study showed that the derivatives gave a wide range of activity from inactive to highly active, which proves it to be of fresh pharmaceutical interest.


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