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Innovative approaches in targeting Cancer Metabolism with small molecules

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Author Affiliations

  • 1Department of Chemical Sciences, Federal University Wukari, Taraba State, Nigeria
  • 2Department of Chemical Sciences, Federal University Wukari, Taraba State, Nigeria
  • 3Department of Biological science, Federal College of Education Okene, Kogi State, Nigeria

Int. Res. J. Medical Sci., Volume 13, Issue (1), Pages 8-12, February,28 (2025)

Abstract

The reprogramming of metabolic pathways is fundamental to cancer cell proliferation and survival, making cancer metabolism a pivotal field for therapeutic advancements. This study investigates the creation and utilization of small molecule inhibitors aimed at critical metabolic routes, such as glycolysis, the tricarboxylic acid (TCA) cycle, and lipid metabolism. By interfering with these pathways, small molecules present a promising approach to hinder tumor growth and enhance the efficacy of current cancer treatments. The research highlights novel strategies in crafting selective and potent inhibitors, tackling challenges like specificity and resistance. Furthermore, it delves into the potential of integrating these small molecules into personalized cancer therapies. The outcomes underscore the promise of targeting metabolic weaknesses as a transformative strategy in cancer treatment.

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