International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

A Dietary Intervention to Reduce weight and its Relation with Leptin Hormone among Obese Adults

Author Affiliations

  • 1Lucknow University, Lucknow, U.P., INDIA
  • 2 Deptt. of Medicine, K.G.Medical University , L.K.O.,U.P., INDIA

Res. J. of Pharmaceutical Sci., Volume 3, Issue (6), Pages 1-3, October,30 (2014)


Obesity is associated with an increased prevalence of metabolic disorder with cardiovascular risk. The increasing incidence of obesity has become important to know the root cause of obesity and how to control the growing incidence of obesity. The prevalence of obesity ranges from 10% to 50%. The increased mortality associated with obesity result primarily from increased risks for cardiovascular disease, high blood pressure, diabetes mellitus and possibly some types of cancer. The paper was prepared at Lucknow City. The 101 patients were selected by purposive sampling method and were studied under two categories; experimental comprising 59 obese subjects and control group 42 obese subjects. The experimental group was examined for their weight and blood leptin level and went under dietary intervention. Leptin is a polypeptide hormone and is circulated with the blood to the brain, predominantly hypothalamus to influence the appetite; energy expenditure and neuro-endocrine function. Problem in the regulation of Leptin Hormone is the cause of change in body weight. High Blood Leptin Level (up to normal limits) decreases the appetite, thus decreasing food intake. The relationship between diet (protein rich diet), weight and blood leptin level was statistically analysed and supported by chi-square.Thus concluding that the diet rich in protein promotes weight reduction by increasing the blood leptin level, vice versa for fat and carbohydrate content is not interfering.


  1. Kopelman P.G., Clinical Obesity in Adults and Children, 3 (2006)
  2. Gut, 53, 1044 (2004)
  3. Jaya Ram B.M., Diabesity, 6-9, (2007)
  4. Harrison’s Principle of Internal Medicine (1) Obesity, 16 (2005)
  5. Kopelmann P.G., C. Grace and Gut,, 1044, (2004)