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PC-Model Studies of 7 methoxy- 2H-3-Aryl-3,4-dihydro-1,3 benzoxazine-Aryl-3, 4-dihydro-4-methyl 7 methoxy -1, 3 benzoxazine Biological activity

Author Affiliations

  • 1 Department of Chemistry, Dr. H. S. Gour Central University, Sagar MP, INDIA

Res. J. of Pharmaceutical Sci., Volume 2, Issue (3), Pages 17-25, May,30 (2013)


An optimization of the reaction conditions in solvent free and solution phase microwave assisted synthesis of (7 Methoxy) 2H-3-Aryl-3, 4-dihydro-1,3 benzoxazine derivatives.The reported methods for the synthesis of substituted benzoxazine derivatives. 2-Hydroxy3-methoxy benzaldehyde and 1-(2-Hydroxyphenyl) ethanol on the reaction with different primary aromatic amines gave methoxy 2-(arylimino) methylphenols and 2-[1-arylimino) ethyl] phenols respectively Synthesized Compound (1). on reduction with sodium borohydride gave 2- methoxy (arylamino) methylphenols and 2- [1-(aryl amino) ethyl] phenols, Synthesized Compound (2). Which further cyclised with formaldehyde to form the final synthetic derivatives as methoxy 2H-3-aryl-3, 4-dihydro-1, 3-benzoxazines and 2H-3-aryl-3, 4-dihydro-4 methyl- 1,3-methoxy benzoxazines. PC-model values, antimicrobial and antifungal activity studies.


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