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Effect of Aluminum on different parts of Brainstem of Old Rats: Haematological, Biochemical and Morphological Study

Author Affiliations

  • 1Department of Advance Science, Nims Institute of Engineering and Technology, NIMS University, Jaipur INDIA
  • 2 Department of Biochemistry, King George’s Medical University, Lucknow, INDIA

Res. J. of Pharmaceutical Sci., Volume 2, Issue (3), Pages 6-11, May,30 (2013)


Aluminum (Al) has identified one of the environmental factors that may cause several neurodegenerative disorders. Generally, uptake of aluminum is greater the older a person becomes. We have orally administered 100 mg AlCl3 (by gavage) to +24 m male rats (n=10) for 90 days. The same number of age and sex matched rats were concurrently administered equal volume of physiological saline. Hematological and serum lipid profile were investigated on 45 and 90 days of Al exposure. Medulla, pons and mid brain were selected for biochemical investigations ie., lipid peroxide levels (LPx), superoxide dismutase (SOD), catalase and glutathione (GSH). Results showed that AlCl3 increases LPO level while the activity of antioxidant enzymes and glutathione was decreased significantly in all the part of brain stem along with decreased activity of antioxidant enzyme. On the basis of results it may conclude that hematology and lipid profiles may be the markers of Al neurotoxicity and mid brain and medulla is more affected area of the brainstem.


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