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In-Silico studies of active constituents of Acalypha Indica against Tyrosinase Kinase for Hyperpigmentation

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Author Affiliations

  • 1Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Kalapatti, Coimbatore, Tamil Nadu, India
  • 2Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Kalapatti, Coimbatore, Tamil Nadu, India

Res. J. of Pharmaceutical Sci., Volume 13, Issue (1), Pages 5-8, June,30 (2024)

Abstract

The aim of the study is to evaluate the effect of caffeic acid and tri-o-methylellagic acid against tyrosinase receptor in the management of hyperpigmentation of skin diseases by molecular docking approach. The computational analysis is carried out by. Auto dock 4 tool. The standard used is kojic acid against the target Tyrosinase receptor with PDB code 5ZOD and the target proteins were retrieved from the protein data bank. caffeic acid and tri-o-methylellagic acid maximum of five interactions with the target amino acid residues when compared to the standard kojic acid which also has a maximum of 5 interaction sites. Hence it can be concluded that caffeic acid and tri-o-methylellagic acid possess promising tyrosinase enzyme blocking activity.

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