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Solubility enhancement and tablet formulation of Albendazole drug

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Author Affiliations

  • 1School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, India
  • 2School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, India
  • 3School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, India

Res. J. of Pharmaceutical Sci., Volume 13, Issue (1), Pages 1-4, June,30 (2024)

Abstract

Albendazole is belongs to BCS Class II which is use as anthelmintic treatment. Major limitation with this drug is its poor solubility. Due to poor solubility it shows poor dissolution rate which lead to poor bioavailability. There are number of methods suggested for increase the solubility of poorly water soluble drug. In this research solid dispersion method was used to improve the solubility. Carriers Hydroxy Propyl Methyl Cellulose (HPMC) and Sodium Carboxy Methyl Cellulose (Sod. CMC) were used to prepare solid dispersion. Various precompression parameters like Angle of Repose, Carr’s Index were performed to check flow properties of blend. Tablets were compressed through 8 station rotator compression machine and evaluated by various tests like friability, disintegration time and hardness. Results of solubility was found that Sod. CMC shown better compare to HPMC. Angle of repose, % Carr’s index and Hausner ratio comes under good to excellent flow property. All the post compression parameters also within limits. Formulation F3 shown better disintegration time (28 min.) compare to other formulation. So it could be concluded that F3 is optimized formulation.

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