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Extraction and characterization of secondary metabolites from Wild Senna and analyse it’s in vitro antimicrobial activity for pharmacological applications

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Author Affiliations

  • 1Amity Institute of Biotechnology, Amity University Chhattisgarh, Raipur-493225, India
  • 2Amity Institute of Biotechnology, Amity University Chhattisgarh, Raipur-493225, India

Int. Res. J. Biological Sci., Volume 14, Issue (1), Pages 13-18, February,10 (2025)

Abstract

The Asteraceae family stands out as one of the largest and most diverse flowering plant families globally, encompassing over 1600 genera and 2500 species. The importance of weeds in pharmacology encompasses a range of valuable contributions to the field of research. Medicinal plants play a crucial role in the pharmaceutical industry, serving as valuable sources of compounds that serve as precursors for drug development. This research delves into the preliminary phytochemical analysis revealing its richness in phenolic and flavonoid secondary metabolites, with the presence of tannins exclusively in its crude methanolic extract. Through qualitative phytochemical analysis, the research has identified the presence of various bioactive compounds such as Phenols, Flavonoids, Terpenoids, Alkaloids, Tannins, Steroids, Carbohydrates, Glycosides, Amino Acids, and Proteins. Weeds constitute a diverse group of plants, and their various species often contain a wide array of chemical compounds. These bioactive compounds can be explored for their pharmacological effects, including anti-inflammatory, antimicrobial, antiviral, and antioxidant activities. Weeds can serve as precursors for the synthesis of pharmaceutical drugs. Understanding the chemical composition of weeds allows researchers to identify and extract compounds that may be used as starting materials or inspiration for drug development. Weeds have been used in traditional medicine by various cultures for centuries. The collective pharmacological potential of its diverse members underscores the importance of further research and exploration of this plant family for its potential contributions to preventive and therapeutic applications in human health. Utilizing weeds as a sustainable resource aligns with the growing emphasis on environmentally friendly and economically viable drug discovery. This article consolidates current knowledge on the medicinal properties and traditional uses of these plants, shedding light on their wide-ranging pharmacological actions including anti-diarrhoeal, antimicrobial, antihypertensive, anti-inflammatory, analgesic, and anti-plasmodial activities.

References

  1. Anisuzzaman, M., Ahsan, M. Q., Kuddus, M. R., & Rashid, M. A. (2014)., Pharmacological Activities of Senna obtusifolia Linn.: A Medicinal Plant of Bangladesh., Bangladesh Pharmaceutical Journal, 17(2), 182-186.
  2. Dedehou, V. F. G. N., Olounladé, P. A., Alowanou, G. G., Azando, E. V. B., & Hounzangbé-Adoté, S. (2016)., A review on medicinal plants of Parkia biglobosa (Mimosaceae-Fabaceae) and Pterocarpus erinaceus (Leguminosae-Papilionoidea)., Journal of Medicinal Plants Studies, 4(6), 132-137.
  3. Jeruto, P., Arama, P. F., Anyango, B., & Maroa, G. (2017)., Phytochemical screening and antibacterial investigations of crude methanol extracts of Senna didymobotrya (Fresen.) HS Irwin & Barneby., Journal of Applied Biosciences, 114, 11357-11367.
  4. Fangbo, A., Wilfred, N.D., Joseph, C.N., Mbaiguinam, M. & Nicolas, N.Y. (2024)., Production, nutritional value and toxicity of Kawal, a fermented product from the leaves of Cassia obtusifolia (L.):A review., European J. Nutr. Food Saf., 16(2), 30-41.
  5. Chandramohan, K., Khan, S. & Husen, A. (2024)., Antimicrobial response, traditional and other potential uses of the genus Senna, In: Antimalarial Medicinal Plants., Edition: 1, Chapter: 16, Taylor & Francis Publication, CRC Press, ISBN: 978-10-03378-39-6.
  6. Momoh, H.,Olaleye, A.A., Sadiq, I.S. & Ahmed, H.(2022)., Phytochemical screening and antimicrobial activity of Cassia obtusifolialeaves extracts., Bayero J. Pure Appl. Sci., 6(13), 277-282.
  7. Nirmala, A. (2024)., Evaluation of phytochemicals, antioxidants and antibacterial activity of Nigella sativa seed extracts., Afr. J. Bio. Sci., 6(9), 5603-5616.
  8. Yousuf, M., Rupam, M.R.I., Halder, S., Manik, M.I.N.&Rashid, M.H.A. (2014)., Antimicrobial activity of different extracts from leaves of aspecific medicinal plant(Senna obtusifolia)., World J. Pharm. Pharmaceu. Sci., 12(3), 204-214.
  9. Vedekoi, J. & Selestin, S.D. (2020)., In vitro antioxidant property and phytochemical constituents of Senna alata., Pharma. Biosci. J., 8(3),15-21
  10. Doughari, J.H. El-mahmood, A.M. & Tyoyina, I.(2008)., Antimicrobial activity of leaf extracts of Senna obtusifolia (L)., African J. Pharm. Pharmacol., 2(1),7-13.
  11. Isah, A., Abdullahi, M.&Tsado, M.J. (2015)., Evaluation of phytochemical, anti-Nutritional and antioxidant potentials of flower and seed methanol extract of Senna alata L. grown in Nigeria., Am. J. Appl. Chem., 3(3), 93-100
  12. Jothirathinam, T. & Victor, V.D. (2016)., Phytochemical screening and antimicrobial activity of Senna uniflora (Mill.) H.S. Irwin & Barneby., World J. Pharm. Res., 5(6), 1608-1619.
  13. Abubakar, A. (2021)., Shoot growth and yield of transplanted Senna obtusifolia (Sickle pod) seedlings in response to different levels (0g, 4g, 8g and 12g) of NPK (15:15:15) fertilizer in Bichi: A potential crop for post Covid-I9 economic recovery., IOSR J. Agri. Vet. Sci., 14(1) 14-20.