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Development and Characterization of Glycyrrhizin Loaded Herbal Lozenges for Mouth Ulcer Treatment

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Author Affiliations

  • 1Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India
  • 2Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India
  • 3Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India
  • 4Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India

Int. Res. J. Biological Sci., Volume 13, Issue (4), Pages 31-36, November,10 (2024)

Abstract

Abrus precatorius Linn. A member of the Fabaceae family, this plant has numerous benefits. The seeds, roots, and leaves are used medicinally. The roots and leaves include astringent, pleasant, emetic, diuretic, and anthelmintic properties. The oral gel dosage form is extensively used in the treatment of mouth ulcers, but it has numerous disadvantages, including blistering, burning, itching, and skin irritation, as well as the fact that it can be swallowed and dissolve in the mouth. To address the aforementioned issue, herbal lozenges were made from Abrus precatorius L. leaves. Microscopy (powder research), morphology, extraction (maceration method), acidic isolation, and thin-layer chromatography were employed to prepare glycyrrhizin acid extract. Then hard lozenges were made and evaluated using a variety of procedures, including average weight and weight fluctuation, friability, hardness testing, disintegration, and moisture content measurement. The leaves contained fibers, trichomes, and xylems. The powder properties of Abrus precatorius leaves revealed the presence of glycyrrhizin. Glycyrrhizin was extracted from a water extract of leaves and identified using chemical testing and Thin Layer Chromatography. Then, lozenges were made in five batches. The first three batches had been consolidated, therefore only the fourth and fifth batches were evaluated. According to observations and data, the fourth batch of lozenges outperformed batch-5 in all tests. So, batch-4 lozenges are preferable. So it is concluded that the lozenge composition can outperform other formulations.

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