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Histopathological Change of Malathion Toxicity in Liver and Kidney of Male Rabbits

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Author Affiliations

  • 1Department of Biochemistry Faculty of Medicine University of Al-Butana, Sudan
  • 2Department of Biochemistry, Kamleen Ahlya College, Sudan
  • 3Department of Surgery and Anesthesiology Faculty of veterinary Medicine University of Al-Butana

Res. J. Animal, Veterinary and Fishery Sci., Volume 12, Issue (2), Pages 1-5, November,24 (2024)

Abstract

Malathion is a widely used organophosphorous pesticide that a large number of populations are undesirably exposing themselves to severe health risk. This study aims to evaluate the histophological change of malathion in rabbits liver and kidneys. The study was conducted on sixty male rabbits divided into three equal groups, twenty rabbits of each group. The rabbits were treated orally with different dose (5 and 15 mg/ kg/day) according tomalathion dose for thirty days. After treatment organs liver and kidney were collected and slides were prepared for reading under light microscope. Urea presented high level in both group low and high dose compared to control, but creatinine presented high level in high dose group. Histopathological change in the liver were mainly represented by; the slide from group (A) low dose indicated mild toxicity of malathion, normal hepatocytes and blood vessels, mild enlargement in the sinusoids and vacuole formations in hepatocytes comparing with the control rabbit while the slide from treatment group (B) high dose showed moderate damage in hepatic tissue including prominent enlargement of sinusoids, congestion of most blood vessels and fatty vacuole formations. Marked in treatment group (B) high dose, highly degeneration of glomeruli, shrinkage of glomeruli and moderate degradation in tubules, also noticed treatment group (A) low dose showed mild shrinkage of glomeruli and mild degradation in tubules of the kidney were noticed. This study concluded that malathion cause toxic effect in low dose and this effect was brightly appear with prolong exposure.

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