International Science Community Association Research Journal of Recent Sciences 2277-2502 7 4 2018 04 2 Kinetic and mechanistic study of ciprofloxacin in aqueous alkaline medium 6 12 EN U. Thakur 1 Department of Zoology, Government Digvijay PG Autonomous College, Rajnanadgaon-491441, Chhattisgarh, India M. Sharma 2 Department of Zoology and Biotechnology, Government V.Y.T.P.G. Autonomous College, Durg-491001, Chhattisgarh, India N. Mishra 3 Department of Zoology and Biotechnology, Government V.Y.T.P.G. Autonomous College, Durg-491001, Chhattisgarh, India K. Damle 4 Department of Zoology, Government Digvijay PG Autonomous College, Rajnanadgaon-491441, Chhattisgarh, India S. Tripathi 5 Department of Zoology, Government Digvijay PG Autonomous College, Rajnanadgaon-491441, Chhattisgarh, India Gajala Tazwar 1 Department of Chemistry, Janki Devi Bajaj Government Girls College, Kota-324001, Rajasthan, India Naveen Mittal 2 Department of Chemistry, Janki Devi Bajaj Government Girls College, Kota-324001, Rajasthan, India Vijay Devra 3 Department of Chemistry, Janki Devi Bajaj Government Girls College, Kota-324001, Rajasthan, India > Research Paper 2017 7 26 2018 04 2 The existence of fluoroquinolone drugs in environment, may harmful to the human health. Hence the present study aimed to oxidative degradation of antibacterial drug ciprofloxacin by hexacyanoferrate(III) (HCF) in aqueous alkali medium at 40& Copyright@ International Science Community Association 730;C temperature. The stoichiometry for the reaction indicates that the oxidation of a mole of ciprofloxacin requires twice moles of HCF. The reaction exhibited first order kinetics with respect to [HCF] and [ciprofloxacin] and less than unit order with respect to [OH-]. The products were also distinguished on the basis of stoichiometric results and confirm by the characterization results of LC-MS and FT-IR analysis. The major product of the reaction obtained by the decarboxylation of the quinolones moiety and hence it may retain the antibacterial activity. From the experimental results the rate law is derived. The activation results with respect to the slowest step of the proposed mechanism were evaluated and thermodynamic parameters are calculated.