International Science Community Association Research Journal of Recent Sciences 2277 - 2502 6 7 2017 06 2 Volumetric Studies of Drug-α-Cyclodextrin Interactions in Water at 298.15 K: Ranitidine Hydrochloride + α -Cyclodextrin + H2O system 23 27 EN Tamiru Sisay Misganaw 1 Department of Development and Environmental Management Studies, University of Gondar, PoBox 196, Gondar, Ethiopia Khuraijam Pushpa 1 Department of Extension Education and Communication and Research Centre, Smt. VHD Central Institute of Home Science (Autonomous), Seshadri Road, Bangalore-560 001, Karnataka, India R. Srilakshmi 2 Department of Extension Education and Communication and Research Centre, Smt. VHD Central Institute of Home Science (Autonomous), Seshadri Road, Bangalore-560 001, Karnataka, India H.S. Surendra 3 Department of Statistics, University of Agricultural Sciences, GKVK, Bangalore-560 065, India Shaikh Vasim R. 1 School of Chemical Sciences, North Maharashtra University, Jalgaon-425001, India Hundiwale Dilip G. 2 School of Chemical Sciences, North Maharashtra University, Jalgaon-425001, India Patil Kesharsingh J. 3 School of Chemical Sciences, North Maharashtra University, Jalgaon-425001, India > Research Paper 2017 4 29 2017 06 2 Density measurements have been carried out for ternary aqueous solutions containing a fixed concentration of & Copyright@ International Science Community Association 61537;-Cyclodextrin and varying concentrations of ranitidine hydrochloride at 298.15 K. These experimental density values have been utilized to evaluate apparent molar volume of the ranitidine hydrochloride in ternary solutions at finite concentrations as well at infinitely dilute solutions. The volume changes due to complexation have been estimated by applying the method developed by Jolicoeur et al. The volume change due to transfer of drug molecule from infinite dilute solutions of aqueous solutions to a solution containing a fixed concentration of &