International Science Community Association Research Journal of Recent Sciences 2277 - 2502 6 10 2017 10 2 Antibacterial screening of novel Mannich bases of 5H-dibenzo [b,f]azepine-5-corboxamide 10 13 EN Legbosi Nwidu Lucky 1 Department of Experimental Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Choba, East West Road, Rivers State, Nigeria Okpe Ohemu Benson 2 Department of Health Communications, Society for Family Health, Abuja, Nigeria Joshi Sheela 1 School of Chemical Sciences, Devi Ahilya Vishvavidyalaya, Khandwa Road, Indore-452001, Madhya Pradesh, India Vyas Kapil 2 School of Chemical Sciences, Devi Ahilya Vishvavidyalaya, Khandwa Road, Indore-452001, Madhya Pradesh, India > Short Communication 2017 7 8 2017 10 2 Current work involves antibacterial screening of Mannich bases of 5H-dibenzo[b,f]azepine-5-carboxamide. A series of Mannich bases of 5H-dibenzo[b,f]azepine-5-carboxamide (4a-4j) were synthesized via Mannich reaction of 5H-dibenzo[b,f]azepine-5-carboxamide with primary/secondary amines and formaldehyde. After characterization of Mannich bases by spectroscopic techniques i.e. UV, IR, 1H NMR and 13C NMR, compounds of series (4a-4j) were screened against pathogen K. pneumoniae. Sulfonamides that used as primary amine during synthesis of mannich bases were also screened against pathogen K. pneumonia and results obtained were compared with synthesized mannich bases. Antibacterial activities of synthesized Mannich bases and sulfonamides have been determined in term of ‘zone of inhibition’. Result obtained shows some of newly synthesized Mannich bases have potent antibacterial activity against pathogen K. pneumoniae. Copyright@ International Science Community Association