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Study of Adverse Effects of Vildagliptin and Insulin Treatment in Diabetes Mellitus Patients

Author Affiliations

  • 1Research and Development Centre, Bharathiar University, Coimbatore – 641046, INDIA
  • 2Department of Biomedical Engineering, SriSiva Subramaniya Nadar College of Engineering, Kalavakkam, Chennai -603110, INDIA

Res. J. Recent Sci., Volume 3, Issue (ISC-2013), Pages 403-407, (2014)


The defective response of the body tissues to insulin leads to Diabetic condition in human beings. The central nervous system which controls the entire motor unit, suffers degeneration that leads to many complications, of which Diabetes Mellitus disease lies most widespread in India. Present-day medicine such as insulin injection and vildagliptin (Dipeptidyl peptidase-4 inhibitor) treatment are associated with serious neuromuscular side effects and nervous impairment. Within this context, aim of our research was to evaluate, by analysing the myocardial dysfunction complexity, the adverse effects induced by vildagliptin in combination with other antidiabetic treatment. Blood glucose level, glycosylated hemoglobin, serum insulin, systolic and diastolic blood pressure, heart rate, myocardial enzymes such as LDH, CK-MB, AST and ECG signals were measured before and after the insulin and vildagliptin treatment in patients. All the above mentioned parameters were altered significantly after the treatment with insulin and vildagliptin. This study may provide evidence to the medical society about the cardiac dysfunction complexity caused by autonomic failure of hypoglycemic actions upon combination therapy of insulin with vildagliptin in diabetes mellitus.


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