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The Influence of Resveratrol on Swarming Differentiation and Expression of Some Virulence Factors of Proteus Vulgaris I

Author Affiliations

  • 1Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida,32306, USA
  • 2Biology Department of Science College, Babylon University, IRAQ

Res. J. Recent Sci., Volume 3, Issue (ISC-2013), Pages 396-402, (2014)


Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin with anti-inflammatory and antioxidant activities. It is produced naturally by several plants especially the roots of the Japanese Knotweed when under attack by pathogens such as bacteria or fungi. In this study we have confirmed that resveratrol has activity against Proteus vulgaris, an important pathogen infecting the urinary tract by investigating its effect on swarming and some virulence factor expression(haemolysin and urease). Swarming inhibition was limited on Luria Bertani agar with and without resveratrol and then bacteria was harvested to assay cell length and the producing of haemolysin and urease. Resveratrol significantly inhibited swarming and virulence factor expression but its effect on growth rate was not significant.


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