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Modified Biginelli reaction: Synthesis of fused Dihydropyrimidones

Author Affiliations

  • 1Department of Chemistry, Tamilnadu College of Engineering, Karumathampatti, Coimbatore-641659, INDIA
  • 2Department of Chemistry, L.R.G. Govt. Arts College for Women, Tirupur-641 604, INDIA
  • 3Department of Chemistry, Sri Ramakrishna Engineering College, Coimbatore-641022, INDIA
  • 4Deapartment of Nano Technology, Sri Ramakrishna Engineering College, Coimbatore-641022, INDIA

Res. J. Recent Sci., Volume 3, Issue (ISC-2013), Pages 370-374, (2014)


A base catalysed, three-component one pot synthesis of quinoline fused dihydropyrimidines by the Biginelli reaction of 4-hydroxyquinolin-2(1H)-ones with aromatic aldehydes and thiourea is reported. The reaction has been carried out in solvent-free condition at microwave irradiation.


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