@Research Paper <#LINE#>Investigating the Effects of Electronic Satisfaction Factors on Forming Electronic Satisfaction of Website Services in Tourism Industry<#LINE#>Haghtalab@Hamed,Zahra@GharibTarzeh,Nabizadeh@Tahere<#LINE#>1-8<#LINE#>1.ISCA-RJRS-2012-202.pdf<#LINE#>Department of Business Management, Torbat-e-Jam Branch, Islamic Azad University, Torbat-e-Jam, IRAN @ Young Researchers Club, Torbat-e-Jam Branch, Islamic Azad University, Torbat-e-Jam, IRAN @ Ferdosi University of Mashhad, IRAN<#LINE#>30/4/2012<#LINE#>16/5/2012<#LINE#> Enormous amount of websites in developing and developed countries show the importance of this industry in the world. In many countries tourism has become the first revenue source. E-satisfaction factors can play a great role in this respect. Using the conceptual model of Masoome (2006), this paper investigated the effects of electronic satisfaction factors on forming electronic satisfaction of website services in tourism industry. A sample size of 140 customers of travel agencies with websites was selected using purposeful sampling. The results showed that 4 factors including website convenience, safety, information, website design, and information have important role in forming e-satisfaction. 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These environmental conditions induce microorganisms to produce varied kinds of antimicrobials which have applications in chemotherapy. Therefore in the present study Acidophilic Bacillus subtilis (B. subtilis) strains were isolated from soil samples of Lonar lake and screened for production of phospholipid antibiotic. The purified phospholipid antibiotic showed broad spectrum activity against the test organisms i.e. Escherichia coli (E. coli), Staphalococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa) and Candida parapsilosis (C. parapsilosis); of these test organisms staphylococcus aureus showed higher sensitivity towards the phospholipids antimicrobial compound. <#LINE#> @ @ Jones B.E., Grant W.D., Duckworth A.W. and Owenson G.G., Microbial diversity of soda lakes, Extremophiles2, 191–200 (1998) @No $ @ @ Grant W.D. and Tindall B.J., The isolation of alkalophilic bacteria, In: Gould GW, Corry ICL (Eds.) 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(Suppl.),85, 1285–1335 (1999) @No $ @ @ Joshi A.A., Kanekar P.P., Sarnaik S. and Kelkar A.,Bacterial diversity of Lonar lake ecosystem, In: Banmeru PK, Banmeru SK, Mishra VR (eds) Biodiversity of Lonar crater. Anamaya, New Delhi, 71–75 (2005) @No $ @ @ Bax R., Multan N. and Verhoef, The millennium bugs-the need for and development of new antibacterials, Int. J. Antimicrob. Agents,16, 51- 59 (2000) @No $ @ @ Enright M., The evolution of resistant pathogens-the case of MRSA, Curr. Opin. Pharmacol.,3, 474-479 (2003) @No $ @ @ Sieradzki K., Roberts R., Haber S. and Tomasz A., The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection, N. Engl. J. Med.,340, 517-523 (1999) @No $ @ @ Saimann L., Tabibi S., Starner T., San G.P., Winokur P., Jia H., McCray P. and Tack B., Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis, Antimicrob. Agent Chemother.,45, 2838-2844 (2001) @No $ @ @ El-Banna N. and Winkelmann G., Pyrrolnitrin from Burkholderia cepacia: antibiotic activity against fungi and novel activities against streptomycetes, J. Appl. Microbiol.,85, 69-76 (1998) @No $ @ @ El-Banna N., Antimicrobial substances produced by air flora, Arab Gulf J. Sci. Res.,21, 134-139 (2003) @No $ @ @ Hofemeister J., Conrad B., Adler B., Hofemeister B., Feesche J. and Kucheryava N.,Genetic analysis of the biosynthesis of non-ribosomal peptide- and polyketide-like antibiotics, iron uptake and biofilm formation by Bacillus subtilis A1/3, Mol. Genet. Genomics, 272, 363–378 (2004) @No $ @ @ Tamehiro N., Okamoto-Hosoya Y., Okamoto S., Ubukata M., Hamada M., Naganawa H. and Ochi K., Bacilysocin, a novel phospholipid antibiotic produced by Bacillus subtilis 168, Antimicrob. Agents Chemother., 46, 315– 320 (2002) @No $ @ @ Pinchuk I.V., Bressollier P., Sorokulova I.B., Verneuil B. and Urdaci M.C., Amicoumacin antibiotic production and genetic diversity of Bacillus subtilis strains isolated from different habitats, Res. Microbiol., 153, 269–276 (2002) @No $ @ @ Pinchuk I.V., Bressollier P., Verneuil B., Fenet B., Sorokulova I.B., Megraud F. and Urdaci M.C., In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics, Antimicrob. Agents Chemother., 45, 3156–3161 (2001) @No $ @ @ Narayan V.V., Hatha M.A., Morgan H.W. and Rao D., Isolation and characterization of aerobic thermophilic bacteria from the Savusavu Hot spring in Fiji, Microbes Environ.,23, 350-352 (2008) @No $ @ @ Abou-Shanab R.A.I., Characterization and 16S rDNA identification of thermo-tolerant bacteria isolated from hot spring, J. appl. Sci. Res.,3, 994-1000 (2007) @No $ @ @ Bergey D.H., Holt J.G., Krieg N.R. and Sneath P.H.A. Bergey’s Mannual of Determinative Bacteriology, 9th ed., (Breed RS, Murray EGD and Smith NR, eds.) Williams and Wilkins, Baltimore,(1994) @No $ @ @ Hosoya Y., Okamoto S., Muramatsu H. and Ochi K. Acquisition of certain streptomycin-resistant (str) mutations enhances antibiotic production in bacteria, Antimicrob. Agents. Chemother.,42, 2041–2047 (1998) @No $ @ @ Bligh E.G. and Dyer W.J., A rapid method for total lipid extraction and purification, Can.J.Biochem.Physiol.,37,911-917 (1959) @No $ @ @ Malu R.A., Dhabhade D.S. and Kodarkar M.S., Diversity in Lonar lake, J. Aquat. Bio.,15, 16–18 (2000) @No $ @ @ Janstova B. and Lukasova J., Heat resistance of Bacillus spp. spores isolated from cow’s milk and farm environment, Acta. Veterinaria. Brno.,70(2), 179-184 (2001) @No $ @ @ Berdy J., Recent developments of antibiotic research and classification of antibiotics according to chemical structure, Adv. Appl. Microbiol.,18, 309-406 (1974) @No <#LINE#>In Silico Charecterization of Keratitis Causing Herpes Simplex Virus (HSV 1) Membrane Proteins using Computational Tools and Servers<#LINE#>Akhilesh@Upgade,Anusha@Bhaskar,Sakshi@Issar,V.@SenthamaraiSelvi<#LINE#>27-31<#LINE#>5.ISCA-RJRS-2012-314.pdf<#LINE#>Center for Advanced Computing and Bioinformatics, CRD PRIST University, Thanjavur, Tamilnadu, INDIA @ Department of Biotechnology, FASC, MITS, Laxmangarh, Rajasthan, INDIA<#LINE#>25/8/2012<#LINE#>31/8/2012<#LINE#> Herpes viruses plays important role in the viral keratitis ocular infection almost all the HSV’s carrying the same virion morphology; icosahedral capsids containing the viral genome are surrounded by an amorphous layer of tegument, and this is encased in a lipid bilayer containing about a dozen different viral glycoprotein’s, 3D structure of proteins makes a pathways towards a drug designing and studies of drug interaction, they may have similar in sequences but differently in biological functions specially in case of the diseases. Present study focused on the characterization viral envelope proteins such as P04290, P06477, P04486 which having a great importance in the keratitis disease caused by HSV. Primary structure analysis shows that proteins are having high leucine residues with some cystein residues; Expasy Protparam studies inferred that all are unstable in nature; Secondary structure shows that some are predominate alpha helices with random coils. Transmembrane region prediction by SOSUI server predicted that P04290 and contain only one transmembrane region while P06477 soluble protein. Four transmembrane regions found in P04486 protein all predicted regions were analyzed by the helical plots using EMBOSS pepwheel 6.1, 3D structure identification done by using Swiss Model and structure validation has been done by PROCHECK and WHAT IF, such a modelled structures provides basic knowledge and good functional analysis for experimentally derived structures. <#LINE#> @ @ Akhtar J. And Shukla D., Viral entry mechanism, cellular and viral mediators of herpes simplex virus entry, FEBS J, 276(24), 7228-7236 (2009) @No $ @ @ Connoliy S.A., Jackson J.O., et. al, Fusing structure and function a structural view of herpes machinery, Nat rev Microbiol, 9(5), 369-381 (2011) @No $ @ @ Akhtar M.J. et. al, A role hepain sulphate in viral surfing, Biochem Biophys Res Commun, 391(1), 176-81, (2010) @No $ @ @ Raquel Naldinho-Souto, Helena Browneand Tony Minson Herpes Simplex Virus Tegument Protein VP16 Is a Component of Primary Enveloped Virions, ncbi.nih.nic.gov.pmc(2009) @No $ @ @ Gupta Manish and Sharma Vimukta, Targeted drug delivery system: A Review, Res.J.Chem.Sci, 1(2) (2011) @No $ @ @ Donnelly M. and Elliott G., Fluorescent tagging of herpes simplex virus tegument protein VP13/14 in virus infection, J. Virol., 75, 2575-2583 (2001) @No $ @ @ Mishra Subhra, Characterization of Protein Interfaces to Infer Protein-Protein Interaction, Res.J.Chem.Sci.,(7),36-40 (2012) @No $ @ @ CLC bio., CLC free Workbench. http://www.clcbio.com/index.php?id=28, 27/10/2006 (2006) @No $ @ @ Gill S.C. and Von Hippel P.H., Calculation of protein extinction coefficients from amino acids sequences data, Anal. Biochem., 182-319 (1989) @No $ @ @ Bachmair A., Finley D. and Varshavsky A., In vivo half-life of aprotein is a function of its amino-terminal residue. Science, 234(4773) @No $ @ @ , 179-186 (1986) @No $ @ @ Gonda D.K. and Bachmair A., et.al., Universality and structure of the N-end rule, J.Biol Chem, 264(28), 16700-16712 (1989) @No $ @ @ Tobias J.W., Shrader T.E., Rocap G. and Varshavsky A., The N-end rule in bacteria, Science, (254), 1374 (1991) @No $ @ @ Ciechanover A., Schwartz A.L., How are substrates recognized by the ubiquitin-mediated proteolytic system?Trends Biochem Sci.,(12), 483–488 (1989) @No $ @ @ Guruprasad K., Reddy B.V.B. and Pandit M.W., Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence, Prot. Eng., (4) 155 (1990) @No $ @ @ Ikai A., Thermostability and Aliphatic Index of Globular Proteins, J. Biochem., (88), 1895 (1980) @No $ @ @ Kyte J. and Doolittle R.F., A simple method for displaying the hydropathic character of a protein, J. Mol. Biol., (157),105 (1982) @No $ @ @ Blanchet C., Combet C., Geourjon C. and Deléage G., MPSA: integrated system for multiple protein sequence analysis with client/server capabilities, TIBS, 25(291), 147 (2000) @No $ @ @ Eisenhaber F., Imperiale F., Argos P. and Froemmel C., Prediction of Secondary Structural Content of Proteins from Their Amino Acid Composition Alone, Proteins Struct. Funct. Design, 25, 157 (1996) @No $ @ @ Takatsugu Hirokawa, Seah Boon-Chieng and Shigeki Mitaku, SOSUI: classification and secondary structure prediction system for membrane proteins, Bioinform. Appl, Note (14), 378 (1998) @No $ @ @ Ramachandran G.N. and Sasiskharan V., Conformation of polypeptides and proteins, Adv.Prot. Chem., (23) 283, (1968) @No $ @ @ Laskowski R.A., Rullmannn J.A., MacArthur M.W., Kaptein R. and Thornton J.M., AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR, Biomol NMR,, 477-486(1996) @No <#LINE#>ORF Investigator: A New ORF finding tool combining Pairwise Global Gene Alignment<#LINE#>DwivediVivek@Dhar,MishraSarad@Kumar<#LINE#>32-35<#LINE#>6.ISCA-RJRS-2012-339.pdf<#LINE#>Department of Bioinformatics, UCST, Dehradun, INDIA @ Department of Biotechnology, DDU University, Gorakhpur, INDIA <#LINE#>10/9/2012<#LINE#>14/9/2012<#LINE#> Bioinformatics tools have become an integral part of the molecular data generated during the DNA fingerprinting of fungal pathogens. Finding and annoting the coding and non coding regions and final product in the form of its amino acid sequences is prerequisite for understanding the evolutionary processes in different pathogenic, fungi, as well as the species used for bioremediation, the medicinal and for biofertilizers applications. In the present study an attempt has been made to develop a tool “ORF Investigator” which not only gives information about the coding and non coding sequences but also can perform pairwise global alignment of different gene/DNA regions sequences. The tool efficiently finds out the ORFs for corresponding amino acid sequences and converts them into their one letter amino acid code declaring their respecting positions in the sequence stretch. The pairwise global alignment between the sequences makes it convenient to detect the different mutations including single nucleotide polymorphism. Needleman and Wunsch algorithms are used for the gene alignment and the coding has been done in PERL language making it suitable for windows user. <#LINE#> @ @ Frishman D., Mironov A., Mewes H.W. and Gelfand M., Combining diverse evidence for gene recognition in completely sequenced bacterial genomes, Nucleic Acids Research, 26(12), 2941-2947 (1998) @No $ @ @ Skovgaard M., Jensen L.J., Brunak S., Ussery D. and Krogh A., On the total number of genes and their length distribution in completemicrobial genomes, Trends in Genetics, 17(8)425-428 (2001) @No $ @ @ Kawarabayasi Y., Complete genome sequence of an aerobic hyperthermophilic crenarchaeon, Aeropyrum pernix K1. DNA Res, , 83-101 (1999) @No $ @ @ Fickett J., Recognition of protein coding regions in DNA sequences, Nucleic Acids Research, 17, 5303-5318 (1982) @No $ @ @ Gribskov M., Devereux J. and Burgess R., The codon preference plot: Graphic analysis of protein coding sequences and prediction of gene expression, Nucleic Acids Research, 12, 539-549 (1984) @No $ @ @ Staden R., Measurements of the effects that coding for a protein has on a DNA sequence and their use in finding genes, Nucleic Acids Research, 12, 551-567 (1984) @No $ @ @ Borodovsky M. and McIninch J., GENMARK: Parallel gene recognition for both DNA strands, Computers and Chemistry, 17(2), 123-133 (1993) @No $ @ @ Krogh A., Mian I.S. and Haussler D., A hidden Markov model that finds genes in E. coli DNA, Nucleic Acids Research, 22, 4768-4778 (1994) @No $ @ @ Salzberg S.L., Delcher A.L., Kasif S. and White O., Microbial gene identification using interpolated Markov models, Nucleic AcidsResearch, 26(2), 544-548 (1998) @No $ @ @ Lukashin A.V. and Borodovsky M., GeneMark.hmm: new solutions for gene finding, Nucleic Acids Research, 26(4), 1107-1115 (1998) @No $ @ @ Besemer J., Lomsadze A. and Borodovsky M., GeneMarkS: a selftraining method for prediction of gene starts in microbial genomes implications for finding sequence motifs in regulatory regions, Nucleic Acids Research, 29(12), 2607-2618 (2001) @No $ @ @ Besemer J. and Borodovsky M., Heuristic approach to deriving models for gene finding, Nucleic Acids Research, 27(19), 3911-3920 (1999) @No $ @ @ ORF investigator Program can be downloaded from https://sites.google.com/site/dwivediplanet/ORFInvestigator website. @No <#LINE#>Groundwater exploration study using Wenner-Schlumberger electrode array through W-4 2D Resistivity Imaging systems at Mahapallipuram, Chennai, Tamilanadu, India<#LINE#>RavindranA.@Antony,H.@Mohd.AbdulKadarPrabhu<#LINE#>36-40<#LINE#>7.ISCA-RJRS-2012-347.pdf<#LINE#>Department of Geology, V.O.Chidambaram College, Manonmaniam Sundaranar University, Thoothukudi, TN, INDIA @ WTS Ltd., Shenzhen, CHINA<#LINE#>17/9/2012<#LINE#>20/9/2012<#LINE#> Groundwater is a very important component of water resources in nature. Since the demand of groundwater increases with population growth, it is necessary to explore groundwater more intensively. In order to determine the existence of usable groundwater for irrigation and drinking purposes in Mahapalipuram, 2D resistivity imaging technique was utilized. The 2-D resistivity imaging technique utilized the Wenner-Schlumberger electrode array configuration because this array is moderately sensitive to both horizontal and vertical structures. The surveys were carried out using W-4 of WTS Ltd, China. The survey is employed with resistivity meter, multicore cable, multi electrodes with wenner and schlumberger array configuration respectively. The collected resistivity data were interpreted using by Res2DINV original software. Three lines were surveyed for groundwater delineation purpose. The length for each survey lines is around 260 meters. At Mahapallipuram, the survey site shows the existence of groundwater. It is indicated by the resistivity values about 10-100 ohm-m. The maximum depth of investigation survey is 39meters. In general the results show that the subsurface is made up of alluvium and clay and the high resistivity values of more than 1000 ohm-m near the surface is due laterite and the end of the depth can be interpreted as mixture of weathered material or bedrock. <#LINE#> @ @ Abdallah S., Al-Zoubi., Abd El-Rahman A., Abueladas,Rami I. Al-Rzouq., ChristianCamerlynck, Emad Akkawi, 3M. Ezarsky, Abu-Hamatteh, Z.S.H., 5Wasim Ali, and Samih Al Rawashdeh. Use of 2D Multi Electrodes Resistivity Imagining for Sinkholes Hazard Assessment along the Eastern Part of the Dead Sea, Jordan, American Journal of Environmental Sciences, 3(94), 230-234 (2007) @No $ @ @ Antony Ravindran A., Characterization of geology of subsurface shallow conglomerate using 2D Electrical Resistivity Imaging at Baragadi, Panna District, Madyapradesh, India, Journal of Applied Science and Environmental Management (JASEM), 14(3), 33-36 (2010) @No $ @ @ Antony Ravindran A. and Ramanujam N., A case study of crystalline limestone intrusion and fault zone identication using 2D ERI technique in Ramco cements, pandalgudi mines, Tamilnadu, International Research Journal of Geology and Mining (IRJGM), 1(2), 011-015 (2010) @No $ @ @ Antony Ravindran A., Ramanujam N., Manimaran G. and Manimaran D., Exploration of Freshwater Movement in Palaeo River and Coastal Environmental Study Using 2D ERI Study in Zirconium Complex, Atomic Energy, Pazhayakayal, Thoothukudi, Research Journal of Earth Sciences, 3(2), 57-62 (2011) @No $ @ @ Griffiths D.H. and Barker R.D., Two-dimensional resistivity imaging and Modeling in areas of complex geology, Journal of Applied Geophysics, 29, 211–226 (1993) @No $ @ @ Loke M.H. and Barker R.D., Rapid least-squares inversion of apparent resistivity pseudosections using a quasi-Newton method, Geophysical Prospecting 44, 131-152 (1996) @No $ @ @ Loke M.H., Electrical imaging surveys for environmental and engineering studies– A practical guide to 2D and 3D surveys (2002) @No $ @ @ Antony Ravindran A. and Ramanujam N., Palaeoscars and landslide prediction using 2D ERI techniques in Ooty area, Nilgiri district, Tamilnadu, Archives of Applied Science Research, 4(1), 262-268 (2012) @No $ @ @ Antony Ravindran A., A case study of granite exploration using 2D ERI technique in Palapathirama Puram, Tirunelveli District, Tamilnadu, Archives of Applied Science Research, 4(1), 280-284 (2012) @No $ @ @ Antony Ravindran A., A beach groundwater impact due to wave and tidal study using 2D eri technique in Van Island, Gulf of Mannar, Tamilnadu, India, Archives of Applied Science Research, 4(1), 669-674 (2012) @No $ @ @ Barker R.D., Depth of investigation of collinear symmetrical four electrode arrays, Geophysics, 54, 1031-1037 (1989) @No $ @ @ Barker R.D., Improving the quality of resistivity sounding data in landfill studies, In S.H. Ward (ed), Geotechnical and environmental geophysics, Environmental and groundwater applications, (2)2, 245-251 (1990) @No $ @ @ Dahlin T. and Loke M.H., Resolution of 2D Wenner resistivity imaging a assessed by numerical modelling, Journal of Applied Geophysics, 38, 237-249 (1998) @No $ @ @ Caleb Adwangashi Tabwassah and Gabriel Ike Obiefun, Geophysical and Geotechnical Investigation of Cham Failed Dam Project, Ne Nigeria, Res. J. Recent Sci., 1(2), 1-18 (2012) @No $ @ @ Antony Ravindran A., Azimuthal Square Array Resistivity Method and Goundwater Exploration in Sanganoor, Coimbatore District, Tamilnadu, India, Research Journal of Recent Sciences,1(4), 41-45 (2012) @No $ @ @ Gwal A.K., Jain Kumar Santosh, Panda Gopal and Gujar Y.S., Study of Ionospheric Perturbations during Strong Seismic Activity by NmF2 Data, Res. J. Recent Sci., 1(1), 2-9 (2012) @No $ @ @ Manimaran D., Groundwater Geochmistry Study Using GIS in and Around Vallanadu Hills, Tamilnadu, India, Res.J.Recent Sci.,1(7), 52-58 (2012) @No $ @ @ Biswas Arkoprovo, Jana Adarsa and Sharma Shashi Prakash, Delineation of Groundwater Potential Zones using Satellite Remote Sensing and Geographic Information System Techniques: A Case study from Ganjam district, Orissa, India, Res.J.Recent Sci., 1(9), 59-66 (2012) @No <#LINE#>Time Varying Stock Market Volatility: The Case of an Emerging Market<#LINE#>Mirza@,@Nawazish,Saeed@SaraMawal<#LINE#>41-46<#LINE#>8.ISCA-RJRS-2012-350.pdf<#LINE#>Lahore School of Economics, PAKISTAN @ Teaching Fellow, Lahore School of Economics, PAKISTAN <#LINE#>19/9/2012<#LINE#>26/9/2012<#LINE#> One of the key determinants for investment in financial markets is the tradeoff between risk and expected returns. While returns are relatively easy to quantify, the risk measurement has always posed challenges for investors. Engle’s (1982) proposition of time varying volatility has seriously challenged the use of standard deviation as a static estimate of risk. This phenomenon is more severe in emerging markets where stock prices are far from Gaussian world. In this paper, we examine the volatility patterns in Karachi Stock Exchange using GARCH framework between 2004 and 2012. We report that a period which witnessed significant growth vis-à-vis market capitalization and trading volumes, volatility clustering was obvious. This implies that all estimates of risk in this period based on standard deviations must be flawed and would have understated the actual risk. This has serious implications because risk assessment plays a vital role in estimating cost of capital, firm valuations and capital budgeting. Based on our finding, we propose that higher order moments of returns should be considered for prudent risk assessment. <#LINE#> @ @ Bachelier L., Theorie de la Speculation, Annales de l’Ecole Normale Superieure de Paris,(1900) @No $ @ @ Markowitz H., Portfolio Selection, Journal of Finance, 7(1), 77-91 (1952) @No $ @ @ Tobin J., Liquidity Preference as Behaviour Towards Risk, Review of Economic Studies, 67, 22-41 (1958) @No $ @ @ Mandelbrot B., The Variation of Certain Speculative Prices, Journal of Business, 36, 394-419 (1963) @No $ @ @ Fama Eugene F., The Behavior of Stock Market Prices, Journal of Business, 38, 34-105 (1965) @No $ @ @ Sharpe W., Capital Asset Prices: A Theory of Market Equilibrium under Conditions of Risk, Journal of Finance, 19(3), 425-442 (1964) @No $ @ @ Lintner J., The Valuation of Risk Assets and the Selection of Risky Investments in Stock Portfolios and Capital Budgets, Review of Economics and Statistics, 47, 13–37 (1965) @No $ @ @ Mossin J., Equilibrium in a Capital Asset Market, Econometrica, 34, 768 – 783 (1966) @No $ @ @ Engle R.F., Autoregressive Conditional Heteroscedasticity with Estimates of the Variance of United Kingdom Inflation, Econometrica, 50, 987-1006 (1982) @No $ @ @ Barra and Higgins, ARCH Models: Properties, Estimation and Testing, Journal of Economic Surveys, 7(4), 305-362 (1993) @No $ @ @ Akgiray V., Conditional Heteroscedasticity in Time Series of Stock Returns: Evidence and Forecast, Journal of Business, 62, 55-80 (1989) @No $ @ @ Brailsford T.J. and Faff R.W, An Evaluation of Volatility Forecasting Techniques, Journal of Banking and Finance, 20, 419-438 (1996) @No $ @ @ Malkiel B. and Xu Y., The Structure of Stock Market Volatility, Working PaperPrinceton University Center for Economic Policy Studies, (1999) @No $ @ @ Yu J., Forecasting Volatility in New Zealand Stock Market, Applied Financial Economics, 12, 192-202 (2002) @No $ @ @ Batra A., Stock Return Volatility Persistence in India: 1973 - 2003, Working Paper ICRIER, New Delhi, India (2003) @No $ @ @ Scott E. and Stewart B., Biased Estimators and Unstable Betas, Journal of Finance, 35(1), 49-55 (1980) @No $ @ @ Berglund T., Liljeblom E. and Loflund A., Estimating Betas on Daily Data for a Small Stock Market, Journal of Banking and Finance, 41-64 (1989) @No @Short Communication <#LINE#>Discovery of New Classes of Ag-Groupoids<#LINE#>M.@Shah,Ahmad@I.,A.@Ali<#LINE#>47-49<#LINE#>9.ISCA-RJRS-2012-290.pdf<#LINE#>Department of Mathematics, Quad-i-Azam University, Islamabad, PAKISTAN @ Department of Mathematics, University of Malakand, PAKISTAN <#LINE#>29/7/2012<#LINE#>8/8/2012<#LINE#>We discover eight new subclasses of AG-groupoids namely; anti-commutative AG-groupoid, transitively commutative AG-groupoid, self-dual AG-groupoid, unipotent AG-groupoid, left alternative AG-groupoid, right alternative AG-groupoid, alternative AG-groupoid and exible AG-groupoid. We prove their existence by providing examples to these classes. We also prove some basic results of these classes and present a table of their enumeration up to order 6. <#LINE#> @ @ Distler A., Shah M. and Sorge V., Enumeration of AG-groupoids, Lecture Notes in Computer Science, Volume 6824/2011, 1-14 (2011) @No $ @ @ GAP: Groups Algorithm and Programming, Version 4.4.12, 2008, (2012) @No $ @ @ Kazim M.A. and Naseerudin M., On almost semigroups, Portugaliae Mathematica.,36(1) (1977) @No $ @ @ Cho J.R., Pusan, Jezek J. and T. Kepka, Praha, Paramedial Groupoids, Czechoslovak Mathematical Journal, 49(124) (1996) Praha @No $ @ @ Stevanovic N. and Protic P.V., Abel-grassmann’s bands, Quasigroups and Related Systems,11(1), 95–101 (2004) @No $ @ @ Stevanovic N. and Protic P.V., Composition of Abel-Grassmann’s 3 -bands, Novi Sad J. Math., 34(2), 175-182 (2004) @No $ @ @ Naseeruddin M., Some studies on almost semigroups and flocks, PhD Thesis, The Aligarh Muslim University, India (1970) @No $ @ @ Shah M., A theoretical and computational investigations of AG-groups, PhD thesis, Quaid-i-Azam University Islamabad, (2012) @No $ @ @ Mushtaq Q. and Yusuf S.M., On Locally Associative LA-semigroup, J. Nat. Sci. Math., XIX(1), 57–62 (1979) @No $ @ @ Shah M., Shah T. and Ali A., On the cancellativity of AG-groupoids, International Mathematical Forum,6(44), 2187–2194 (2011) @No $ @ @ Howie J.M., Fundamentals of Semigroup Theory, Clarendon Press, Oxford, (2003) @No <#LINE#>Using Ultrasonic Sensor for Blind and Deaf persons Combines Voice Alert and Vibration Properties<#LINE#>A.@MahdiSafaa,Muhsin@AsaadH.,I.@Al-MosawiAli<#LINE#>50-52<#LINE#>10.ISCA-RJRS-2012-308.pdf<#LINE#>Technical Institute – Babylon, IRAQ<#LINE#>17/8/2012<#LINE#>31/8/2012<#LINE#> Persons who are blind and deaf frequently suffering when exercising the most basic things of daily life and that could put lives at risk while traveling, due to the lack of necessary equipment in our country that provides them with assistance to avoid the risk, so came the idea of this research in the design and manufacturing ultrasonic sensor handheld combines the properties of sound monition and that benefit the blind and vibrating alert feature, which benefit from the experience of deafness. Sensor can detect obstacles within the designed range (150 cm) to avoid the blind person through the issuance of distinctive sound or vibration can be issued by the sense of the deaf by putting his finger on the button at the top of the device vibrate when there is a risk. <#LINE#> @ @ Hub Andreas, Diepstraten Joachim. and Ertl Thomas, Design and Development of an Indoor Navigation and Object Identification System for the Blind, ASSETS'04, Atlanta, Georgia, USA, October 18-20, (2004) @No $ @ @ Iwan Ulrich and Johann Borenstein, The Guide Cane -Applying Mobile Robot Technologies to Assist the Visually Impaired, IEEE Transactions on Systems, Man and Cybernetics - Part A: Systems and Humans, 31(2), 131-136 (2001) @No $ @ @ Mewada Shivlal and Singh Umesh Kumar, Performance Analysis of Secure Wireless Mesh Networks, Res.J.Recent Sci., 1(3), 80-85 (2012) @No $ @ @ Gulati Rishabh, GPS Based Voice Alert System for the Blind, International Journal of Scientific & Engineering Research, 2(1), (2011) @No $ @ @ Tiwari Nitin, Solanki Rajdeep Singh and Pandya Gajaraj Singh, Intrusion Detection and Prevention System (IDPS) Technology- Network Behavior Analysis System (NBAS), ISCA J. Engineering Sci. 1(1), 51-56 (2012) @No $ @ @ Shahaboddin Shamshirband and Ali Za'fari, Evaluation of the Performance of Intelligent Spray Networks Based On Fuzzy Logic, Res.J.Recent Sci., 1(8), 77-81 (2012) @No $ @ @ Nagadeepa N., Enhanced Bluetooth Technology to Assist the High Way Vehicle Drivers, Res.J.Recent Sci. , 1(8), 82-85 (2012) @No $ @ @ Wang Y., Jia X. and Lee H.K., An Indoors Ultrasonic Positioning System Based on Ultrasonic Local Area Network Infrastructure, Proceedings of the 6th International Symposium on Satellite Navigation Technology Including Mobile Positioning & Location Services, (2003) @No $ @ @ McKerrow Phillip J. and Antoun Sherine M. ,Research Into Navigation with CTFM Ultrasonic Sensors, ION 63rd annual meeting, Cambridge, Massachusetts, April 23-25 (2007) @No $ @ @ Ramiro Velázquez ,Wearable Assistive Devices for the Blind, Wearable and Autonomous Biomedical Devices and Systems for Smart Environment: Issues and Characterization, LNEE 75, Springer, 331-349 (2010) @No <#LINE#>Screening of the Cassia fistula Flowers Extract for the Anti-Acne Activity<#LINE#>Ranjit@Singh,Sankar@C.<#LINE#>53-55<#LINE#>11.ISCA-RJRS-2012-312.pdf<#LINE#>KMCH College of Pharmacy, Department of Pharmaceutics, Kovai Estate, Kalapatti road, Coimbatore – 641035, Tamil Nadu, INDIA <#LINE#>21/8/2012<#LINE#>25/8/2012<#LINE#> Extract of Cassia fistula flowers were screened for their in vitro antimicrobial activity using agar disc diffusion method. The antimicrobial activity of methanolic extract of Cassia fistula flowers were studied against acne causing bacteria, namely Staphylococcus epidermidis. Methanolic extract of Cassia fistula flowers possessed highest antibacterial activity against S. epidermidis. Minimum inhibitory concentration (0.42 mg/mL) and antimicrobial screening (10.01± 0.04 mg/ml) against S. epidermidis were also observed for methanolic extract of Cassia fistula flowers. Phytochemical screening revealed the presence of alkaloids, tannins, saponins, anthraquinones, anthocyanides flavonoids, glycosides and terpenoids which indicates that these phytoconstituents may be responsible for their anti-acne activity. <#LINE#> @ @ Khosravi A. and Behzadi A., Evaluation of the antibacterial activity of the seed hull of Quercus barantii on some gram-negative bacteria, Pak. J. Med. Sci,22, 429-432 (2006) @No $ @ @ Duraipandiyan V. and Ignacimuthu S. Antibacterial and antifungal activity of Cassia fistula L. : an ethnomedicinal plant, J Ethnopharmacol, 112(3), 590-594 (2007) @No $ @ @ Panda H., Handbook of medicinal herbs with uses, 140-142 (2004) @No $ @ @ Bauer A.W., Kirby W.M.M., Sherris J.C. and Turck M., Antibiotic susceptibility testing by a standardized single disk method, Am J Clin Pathol, 45, 493-496 (1966) @No $ @ @ De Souza S.M., Delle-Monache F and Smânia Jr A, Antibacterial activity of coumarins, Z Naturforsch C, 60, 693-700 (2005) @No $ @ @ Kartnig T., Still F. and Reinthaler F., Antimicrobial activity of the essential oil of young pine shoots (Picea abies L.), J Ethnopharmacol, 35, 155-157 (1991) @No $ @ @ Young H.L., In-Hwan K. and Jung-Ju S., In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes, J Microbiol, 10, 473-477(2007) @No $ @ @ Mahesh B. and Satish S., Antimicrobial activity of some important medicinal plant against plant and human pathogens, World J Agric Sci., 4(S), 839-843 (2008) @No $ @ @ Sher A., Antimicrobial activity of natural products from medicinal plants, Gomal J Med Sci., 7(1), 72-78 (2009) @No $ @ @ Harbone J.B., Phytochemical Methods, Chapman and Hall, Ltd., London, 49-188 (1973) @No $ @ @ Singh A.P., Pharmacognosy Magazine, 2(6), 87-89 (2006) @No $ @ @ Guay D.R., Topical clindamycin in the management of acne vulgaris, Expert Opin Pharmacother, 8(15), 2625-2664 (2007) @No $ @ @ Plewig G. and kligman A.M., Acne and rosacea, 3rd ed. Berlin, Germany: Springer – Verlag, 73(1), 41-45 (1993) @No $ @ @ Webster G.E., Inflammation in acne vulgaris, Jam acad Dermatol, 33, 247-253 (1998) @No $ @ @ Strauss J., Krowchuk D., Leyden J., Lucky A., Shalita A., Siegfried E., Thiboutot D. and Vanvoorhees A et al., Guidelines of care for acne vulgaris management, J American Acad Derm, 56(4), 651–663 (2007) @No $ @ @ Vijayalakhmi, Tripura A. and Ravichandiran V., Development and evaluation of anti acne products from Terminlia Arjuna bark, Int J of chem. Tech research, 3(1), 320-327 (2011) @No $ @ @ Hisham R.I. and Imranul M.D., Potent antimicrobial action of triclosan- lysozyme complex against skin pathogens mediated through drug – targeted delivery mechanism, European J pharm sci,42, 130-137 (2011) @No <#LINE#>Drude Formalism Study of The Giant Magnetoresistance in Fe(t)/Cu/Fe Trilayers<#LINE#>J.I.@Uba,Ekpunobi@A.J.,P.I.@Ekwo<#LINE#>56-58<#LINE#>12.ISCA-RJRS-2012-327.pdf<#LINE#>Department of Physics, Nwafor Orizu College of Education, P.M.B. 1734, Onitsha, Anambra, NIGERIA @ Department of Physics/Industrial Physics, Nnamdi Azikiwe University, P.M.B. 5025, Awka, Anambra, NIGERIA<#LINE#>6/9/2012<#LINE#>18/10/2012<#LINE#> The recently developed Drude-like model for resistivity in metallic multilayers is applied to Fe(t)/Cu(10A)/Fe(10A) trilayer systems. The basic GMR characteristics deduced conform qualitatively to reports communicated in literature. Our analyses show that the Fuchs-Sondheimer theory of thin film resistivity is not valid for layered structures and spin-dependent scattering in the bulk is the dominant mechanism for GMR in the investigated systems. <#LINE#> @ @ Baibich M.N., Broto J.M., Fert A., Nguyen Van Dau F., Petroff F., Eitenne P., Creuzet G., Friederich A. and Chazelas J., Giant magnetoresistance of (001)Fe/(001)Cr magnetic superlattices, Phys. Rev. Lett61, 2472 - 2475 (1988) @No $ @ @ Binasch G., Grunberg P., Saurenbach F. and Zinn W., Enhanced magnetoresistance in layered magnetic structures with antiferromagnetic interlayer exchange, Phys. Rev. B, 39, 4828 - 4830 (1989) @No $ @ @ Lu L., Lu G., Zhang Z., Gao C., Yu T. and Chen P., Giant magnetoresistance of Co/ITO multilayers, Solid State Commun.,149, 2254-2256 (2009) @No $ @ @ Papp G. and Borza S., Giant magnetoresistance in a two-dimensional electron gas modulated by periodically repeated magnetic barriers, Solid State Commun.,150, 2023 - 2027 (2010) @No $ @ @ Lu M-W. and Yang G-J., Magnetoresistance effect in a hybrid ferromagnetic/semiconductor nanostructure, Solid State Commun.,141, 248 - 251 (2007) @No $ @ @ Elsafi B., Trigui F. and Fakhfakh Z., Effects of bulk and interface scattering on giant magnetoresistance in the Co/Cu multilayer systems, Comput. Mater. Sci., 50(2), 800 - 804 (2010) @No $ @ @ Vedyayev A., Ryzhanova N. and Dieny B., Quantum effects in the giant magnetoresistance (GMR) of magnetic multilayers, Physica A, 241, 207 - 215 (1997) @No $ @ @ Oomi G., Sakai T., Uwatoko Y., Takanashi K. and Fujimori H., Magnetoresistance of magnetic multilayers at high pressure, Physica B,239, 19 - 28 (1997) @No $ @ @ Yu. T, Li X-Q., Li D-G., Hao S-F., Wang L-M., Zhang Z-G., Wu G.H., Zhang X.X., Li Q-L. and Chen P., Magnetic property and magnetoresistance in Fe/ITO multilayers, J. Magn. Magn. Mater., 320, 2185 - 2189 (2008) @No $ @ @ Lu L., Yang Y-X., Gao C., Xiong Y-Q. and Chen P., Temperature dependence of magnetoresistance in Co/ITO multilayers, J. Alloys. Comp., 492, 61 - 64 (2010) @No $ @ @ Uba I., Ekpunobi A.J. and Ekwo P.I., Magnetoresistance – temperature relationship: calculus of variation approach, J. Sci. and Arts,4(17), 509 - 512 (2011) @No $ @ @ Hood R.Q. and Falicov L.M., Boltzmann equation approach to the negative magnetoresistance of ferromagnetic – normal metal multilayers, Phys. Rev. B,46, 8287 - 8296 (1992) @No $ @ @ Barnas J., Fuss A., Camley R.E., Grunberg P. and Zinn W., Novel magnetoresistance effect in layered magnetic structures: Theory and experiment, Phys. Rev. B,42, 8110 - 8120 (1990) @No $ @ @ Camblong H.E. and Levy P.M., Novel results for quasiclassical linear transport in metallic multilayers, Phys. Rev. Lett., 69, 2835 - 2838 (1992) @No $ @ @ Barnas J and Bruynseraede Y., Electronic transport in ultrathin magnetic multilayers, Phys. Rev. B53, 5449 - 5460 (1996) @No $ @ @ Camblong H.E., Linear transport theory of magnetoconductance in metallic multilayers: A real – space approach, Phys. Rev. B,51, 1855 - 1865 (1995) @No $ @ @ The model and its derivation are part of still – in – progress doctorate work of U.J.I. @No $ @ @ Thanh N.T., Tu L.T., Ha N.D., Kim C.O., Kim C., Shin K.H. and Parvatheeswara Rao B., Thickness dependence of parallel and perpendicular anisotropic resistivity in Ta/NiFe/IrMn/Ta multilayer studied by anisotropic magnetoresistance and planar Hall effect, J. Appl. Phys.,101, 053702-1-5 (2007) @No $ @ @ Sondheimer E.H., The mean free path of electrons in metal, Adv. Phys.50(6), 466 - 537 (2001) @No @Review Paper <#LINE#>Overcoming Additional Investment to Meet Customer Needs by Applying Smed/Qco Tool - A Study<#LINE#>Nystha@Baishya,SathishU.@Rao,Sharath@Diwakar<#LINE#>59-63<#LINE#>13.ISCA-RJRS-2012-152.pdf<#LINE#> Manipal Institute of Technology, Manipal, Karnataka, INDIA @ Mechanical and Manufacturing Engineering, Manipal Institute of Technology, Manipal, Karnataka, INDIA @ BANP/PJ-CRR21, RBIN, Bangalore, Karnataka, INDIA <#LINE#>31/3/2012<#LINE#>7/6/2012<#LINE#> Nowadays the market is increasingly demanding more customized products, thus making the manufacturers under the pressure of cost reduction, to survive in the highly competitive market. Working on this, Robert Bosch India (RBIN) Limited, Bangalore Plant (BanP) designs and produces diesel systems which make vehicles more cleaner and economical. To be the world’s leading manufacturer of diesel injection systems, Bosch has to manufacture its very own design to fulfill the requirements for every customers, economically. Fuel injection equipment in diesel engine is the “Heart of the Engine” and plays a major role in its performance, emissions and reliability. Hot Forged Rail (HFR) finds its application in common rail fuel injection system, which stores the fuel at high pressure (1600bar). And at the same time, the pressure oscillation, which is generated due to the high pressure pump delivery and the injection of fuel are damped by the rail volume. Its design varies according to customer requirement and engine design. Therefore, BanP has to produce different types of rails to complete diesel market in India. In order to be customer centric and productive, BOSCH follows Bosch Production Systems (BPS), the elements of BPS in Lean manufacturing are Value Stream Mapping (VSM), Value Stream Design (VSD) and Value Stream Planning (VSP). The Single Minute Exchange of Die (SMED) is one important lean manufacturing tool to reduce waste and improve production flexibility, allowing lot size reduction and manufacturing flow improvements. Quick Change Over (QCO) is a set of activities (preparation, changing and adjustment) which are being carried out in between the production of two varieties to reduce changeover time and to reach the optimum production running. The proposed SMED approach was tested for injection machines changeovers in the automotive industry and the implementation had enabled reduction in setup time, through company’s internal resources reorganizations without the need for significant investment. So, the objective of the present study is to implement the same technique in RBIN, BanP, HFR production line to reduce the changeover time by �65% and improve availability by 15% using SMED/QCO tool approach, thereby eliminating the possibility of investing on a new production line to meet the customer demand. <#LINE#> @ @ Quick Change Over for Operators, The Single Minute Exchange of Dies System Productivity Press, Portland, Oregon, ISBN: 1 - 56 327 - 125 – 7,(2008) @No $ @ @ A Revolution in Manufacturing: The SMED System, Shigeo Shingo; Productivity Press, Portland, Oregon, ISBN: 0 - 915 299 - 03 – 8(2001) @No $ @ @ John P. Leschke, An Empirical Study of the SetupReduction Process, Production And Operations Management, 5(2) (1996) @No $ @ @ Gilmore M. and Smith D.J., Setup reduction in pharmaceutical manufacturing: an action research study, International Journal of Operations and Production Management, 16(3), 4–17 (1996) @No $ @ @ Moxham C. and Greatbanks R., Prerequisites for the implementation of the SMED methodology: A study in a textile processing environment, International Journal of Quality, Reliability, 18(4), 404–414 (2001) @No $ @ @ Johansen P. and McGuire K. J., A Lesson in SMED With Shigeo Shingo, Industrial Engineering, 8(10), (1986) @No $ @ @ Cakmakci M., Process improvement: performance analysis of the setup time reductionSMED in the automobile industry, International Journal of Advanced Manufacturing Technology,41, 168–179 (2009) @No $ @ @ Idle Time Reduction in metal working through quick changeover techniques, A seminar held at UNIDO-ICAMT Building, CMTI Campus, Bangalore, 27 October (2010) @No $ @ @ Shams Rahman, Tritos Laosirihongthong, Amrik S. Sohal, Impact of lean strategy on operational performance: a study of Thai manufacturing companies, Emerald 21, (2010) @No $ @ @ B. Suresh Kumar and S. Syath Abuthakeer, “Implementation of Lean Tools and Techniques in an Automotive Industry”. Journal of Applied Sciences,: pp1032-1037,(2012) @No $ @ @ http://www.aleanjourney.com/2010/08 @No $ @ @ http://en.wikipedia.org/wiki/Single_Minute_Exchange_of_Die @No $ @ @ www.wikipedia.org/wiki/Single_minute_exchange of _die @No <#LINE#>Investigating Flow Patterns in Wind Catchers with underground Tunnels using Computational Fluid Dynamics<#LINE#>Morteza@Amooie,HooshmandAli@Aini,Hassanpanah@Mostafa,Shadi@Tasdighi<#LINE#>64-69<#LINE#>14.ISCA-RJRS-2012-274.pdf<#LINE#>Department of civil engineering, Bandar Anzali Branch, Islamic Azad University, Bandar Anzali, IRAN @ Department of civil engineering, Roudbar Branch, Islamic Azad University, Roudbar, IRAN @ Department of Mechanical Engineering, Sharif University of Technology, Tehran, IRAN<#LINE#>1/7/2012<#LINE#>9/8/2012<#LINE#> Taking the advantage of wind energy in ventilating residential places has been focused on since old times. Surely, using wind is important in making healthy and comfortable rooms for work and life, especially from the view point of enhancing the physical and mental performance of people and reducing consumption of non-renewing fuels. When wind flows around a building or enters from one side and then exits from the other side, natural ventilation occurs. Windscops can be used for pushing the air out to provide conditions to make a natural flow of air. Windtowers can be used for pulling the air inside and then let it flow freely in the room, So, A combination of windtowers and windscops could provide a natural flow through the area to be ventilated. A special kind of windtower can be used in a little distance from the building so that they guide air into underground channels into the building; used air after ventilating will exit through the windscop. In this paper, after describing how windtowers work, using CFD the performance of windtowers is investigated. For this aim at first geometrical model and meshing was performed in GAMBIT, then FLUENT was used to investigate the flow pattern in prescribed windtowers. Results of the analysis in form of flow pattern and velocity contours in X and Y direction are presented. <#LINE#> @ @ Bahadory Nejad M. and Dehghani A., Windcatchers; Iranian Masterpiece of Engineering, Nashr Ketab Daneshgahi, 190-198 (2008) @No $ @ @ World Energy Council, Energy Efficiency Policies around the World: Review and Evaluation, World Energy Council, 8-12 (2008) @No $ @ @ McCarty Consultant Engineers, Windscops (wind skeletal considerations in buildings) (2008) @No $ @ @ Shojaie Fard M. and Noorpour Hashtroudi A., Introduction to Computational Fluid Dynamics, Iranian University of Science and Technology (2007) @No $ @ @ Soltani M., Rahimi Asl R., Computational Fluid Dynamics using Fluent, Tarrah (2007) @No $ @ @ Nejad A.T., Storm of Inattention against Windcatchers in Yazd, Jam e Jam Newspaper, 15 (2011) @No $ @ @ Vetr M.G., Investigating Vulnerability of the Tallest Windcatcher around the Globe, Yazd Dolat Abad garden against Wind and Earthquake, First International Conference on Seismic Retrofitting (2006) @No $ @ @ Wolfgang R., Turbulence Models and their Application in Hydraulic: A state-of-the art Review. International Association for Hydraulic Research, Delft, 27 (1984) @No $ @ @ Thundil Karuppa Raj R. and Ramsai R., Numerical study of fluid flow and effect of inlet pipe angle in catalytic converter using CFD, Res. J. Recent Sci, 1(7), 39-44 (2012) @No $ @ @ Ipatova V.M., Convergence of Numerical Solutions of the Data Assimilation Problem for the Atmospheric General Circulation Model,Res. J. Recent Sci., 1(6)16-21 (2012) @No <#LINE#>OncmiRs: Small Noncoding RNA with Multifaceted Role in Cancer<#LINE#>Joseph @ Baby,M.@NairVrundha<#LINE#>70-76<#LINE#>15.ISCA-RJRS-2012-313.pdf<#LINE#> Interdisciplinary Research Centre, Department of Biotechnology, Malankara Catholic College, Mariagiri, Kaliakkavilai, TN, INDIA <#LINE#>24/8/2012<#LINE#>11/10/2012<#LINE#> Several advancements in cancer research occur till date and the involvement of miRNAs in cancer threw new hope to cancer therapy. OncomiRs are miRNAs which plays significant role in cancer. It serves as a double edged sword in cancer because up- regulation and down- regulation of miRNAs are observed in cancerous cells and hence acts as oncogenes and tumor suppressors respectively. Since, cancer is a disease affecting multiple cell types and with different stages, treatment of it remains as a biggest challenge. miRNA turns to be a promising therapeutic tool in cancer due to its regulatory role. This review briefs the multiple role of miRNA in cancer with special emphasis on tumor microenvironment, cell proliferation, angiogenesis, metastasis and apoptosis. Moreover the tumor suppressor and oncogenenic role of miRNAs are also discussed. <#LINE#> @ @ Bartel D.P., MicroRNAs: Genomics, biogenesis, mechanism and function, Cell, 116, 281-97 (2004) @No $ @ @ Lee C., Rosalind Feinbaum, L. Rhonda Ambros, Victor, The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Anitsense Complementary to lin-14, Cell, 75,843-854 (1993) @No $ @ @ Lee R.C. and V. Ambros, An extensive class of small RNAs in Caenorhabditis elegans,Science, 294, 862-864 (2001) @No $ @ @ Pasquinelli A.E., Reinhart B.J., Slack F., Martindale M.Q. and Kuroda M.I. et al., Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA, Nature, 408, 86-89 (2000) @No $ @ @ Lu J., Getz G., Miska E.A., Alvarez-Saavedra E. and Lamb J., et al., Microrna expression profiles classify human cancers, Nature, 435, 834-8 (2005) @No $ @ @ Calin G.A., Sevignani C. and Dumitru C., et al., Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers, PNAS, 101, 2999-3004 (2004) @No $ @ @ Yao Q., Xu H., Zhang Q.Q., Zhou H. and Qu L.H., MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4(PDCD4) in HeLa cervical carcinoma cells, Biochem Biophys Res Commun,388(3), 539-42 (2009) @No $ @ @ Feng S., Cong S., Zhang X., Bao X., Wang W., Li H., Wang Z., Wang G., Xu J., Du B., Qu D., Xiong W., Yin M., Ren X., Wang F., He J. and Zhang B., MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells, Nucleic Acids Res., 39(15), 6669-78 (2011) @No $ @ @ Yan D., Zhou X., Chen X., Hu D.N., Dong X.D., Wang J., Lu F., Tu L. and Qu J., MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met, Invest Ophthalmol Vis Sci, 50(4), 1559-65 (2009) @No $ @ @ Huang Z., Huang S., Wang Q., Liang L., Ni S., Wang L., Sheng W., He X. and Du X., MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma, Cancer Res., 71(7), 2582-9 (2011) @No $ @ @ Musumeci M., Coppola V., Addario A., Patrizii M., Maugeri-Saccà M., Memeo L., Colarossi C., Francescangeli F., Biffoni M., Collura D., Giacobbe A., D'Urso L., Falchi M., Venneri M.A., Muto G., De Maria R. and Bonci D., Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer, Oncogene,30(41), 4231-42 (2011) @No $ @ @ Mbeunkui F. and Johann D.J., Jr. Cancer and the tumor microenvironment: a review of an essential relationship, Cancer Chemother Pharmacol., 63(4), 571–582 (2009) @No $ @ @ Suarez Y., Fernandez-Hernando C., Yu J., Gerber S.A., Harrison K.D., Pober J.S., Iruela-Arispe M.L., Merkenschlager M. and Sessa W.C., Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis, Proc Natl Acad Sci U S A,105, 14082–14087 (2008) @No $ @ @ le Sage C., Nagel R., Egan D.A., Schrier M., Mesman E., Mangiola A., Anile C., Maira G., Mercatelli N., Ciafrè S.A., Farace M.G. and Agami R., Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation, EMBO J., 26(15), 3699-708 (2007) @No $ @ @ Martin M.M., Lee E.J., Buckenberger J.A., Schmittgen T.D. and Elton T.S., MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts, J Biol Chem., 281(27), 18277-84 (2006) @No $ @ @ Bonauer A., Carmona G., Iwasaki M., Mione M., Koyanagi M., Fischer A., Burchfield J., Fox H., Doebele C., Ohtani K., Chavakis E., Potente M., Tjwa M., Urbich C., Zeiher A.M. and Dimmeler S., MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice, Science,324(5935), 1710-3 (2009) @No $ @ @ Nikolic I., Plate K.H. and Schmidt M.H., EGFL7 meets miRNA-126: an angiogenesis alliance, J Angiogenes Res., 2(1), 9 (2010) @No $ @ @ Bhaumik D., Scott G.K., Schokrpur S., Patil C.K., Campisi J. and Benz C.C., Expression of microRNA-146 suppresses NF-nB activity with reduction of metastatic potential in breast cancer cells, Oncogene,27, 5643–7 (2008) @No $ @ @ Ma L., Teruya-Feldstein J. and Weinberg R.A., Tumour invasion and metastasis initiated by microRNA-10b in breast cancer, Nature, 449, 682–8 (2007) @No $ @ @ Huang Q., Gumireddy K. and Schrier M., et al. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis, Nat Cell Biol, 10, 202–10 (2008) @No $ @ @ Xu P., Vernooy S.Y., Guo M. and Hay B.A., The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism, Curr Biol,13, 790–795 (2003) @No $ @ @ Chan J.A., Krichevsky A.M. and Kosik K.S., MicroRNA21 is an antiapoptotic factor in human glioblastoma cells, Cancer Res.,65, 6029-6033 (2005) @No $ @ @ Calin G.A., C.D. Dumitru M. Shimizu R. Bichi and S. Zupo et al., Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukaemia, Proc. Natl. Acad. Sci. USA., 99,15524-15529 (2002) @No $ @ @ Cimmino A., Calin G.A., Fabbri M. and Ferracin M. et al., MiR15 and miR-16 induce apoptosis by targeting BCL2. PNAS, 102, 13944-13949 (2005) @No $ @ @ Volinia S., Calin G.A. and Liu C.G. et al., A microRNA expression signature of human solid tumors defines cancer gene targets, Proc. Natl Acad. Sci. USA., 103, 2257-2261 (2006) @No $ @ @ Ciafre S.A., Galardi S., Mangiola A., Ferracin M. and Liu C.G. et al., Extensive modulation of a set of microRNAs in primary glioblastoma, Biochem. Biophys. Res. Commun., 334, 1351-1358 (2005) @No $ @ @ Esquela-Kerscher A., Trang P., Cheng A., Ford L. and Weidhaas J. et al., The let-7 microRNA reduces tumor growth in mouse models of lung cancer, Cell Cyc., 7, 759-64 (2008) @No $ @ @ Bhattacharya R., Nicoloso M., Arvizo R., Wang E. and Cortez A. et al., Mir-15a and MiR-16 control Bmi-1 expression in Ovarian Cancer, Cancer Res., 69, 9090-9095 (2009) @No $ @ @ Tanic M., Yanowsky K., Rodriguez-Antona C., Andrés R., Márquez-Rodas I., Osorio A., Benitez J. and Martinez-Delgado B., Deregulated miRNAs in Hereditary BreastCancer Revealed a Role for miR-30c in Regulating KRAS Oncogene, PLoS One. 7(6), e38847 (2012) @No $ @ @ Noguchi S., Mori T., Otsuka Y., Yamada N., Yasui Y., Iwasaki J., Kumazaki M., Maruo K. and Akao Y., Antioncogenic microRNA-203 induces senescence by targeting E2F3 protein in human melanoma cells, J Biol Chem., 287(15), 11769-77 (2012) @No $ @ @ Tao J., Wu D., Li P., Xu B., Lu Q., Zhang W., microRNA-18a, a member of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells, Mol Med Report,5(1), 167-72 (2012) @No $ @ @ Choong C. and Say Y., Knockdown of -Synuclein Enhances Susceptibility to Staurosporine Induced Apoptosis in Human Melanoma SK-MEL28 Cells, Journal of Biological Sciences, 11, 135-145 (2011) @No $ @ @ He L., Thomson J.M., Hemann M.T., Hernando-Monge E. and Mu D. et al., A microRNA polycistron as a potential human oncogene, Nature, 435, 828-833 (2005) @No $ @ @ Virginie O., Bennett M.J., Walker J.C. and Ma C. et al., Mir-19 is a key oncogenic component of mir-17-92, Genes Dev.,23, 2839-2849 (2009) @No $ @ @ Iorio M.V., Ferracin M., Liu C.G., Veronese A. and Spizzo R. et al., MicroRNA gene expression deregulation in human breast cancer, Cancer Res., 65, 7065-7070 (2005) @No $ @ @ Zhu S., Si M.L., Wu H. and Mo Y.Y., MicroRNA-21Targets the tumor suppressor gene Tropomyosin 1 (TPM1), J.Biol.Chem., 282, 14328-14336 (2007) @No $ @ @ Brueckner B., Stresemann C., Kuner R., Mund C. and Musch T. et al., The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function, Cancer Res., 67, 1419-1423 (2007) @No $ @ @ Wang Y., Rathinam R., Walch A. and Alahari S.K., ST14 (suppression of tumorigenicity 14) gene is a Target for miR-27b and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation, J. Biol. Chem., 284,23094-23106 (2009) @No $ @ @ Streicher K.L., Zhu W., Lehmann K.P., Georgantas R.W., Morehouse C.A., Brohawn P., Carrasco R.A., Xiao Z., Tice D.A., Higgs B.W., Richman L., Jallal B., Ranade K. and Yao Y.A, Novel oncogenic role for the miRNA-506514 cluster in initiating melanocyte transformation and promoting melanoma growth, Oncogene, 31(12),1558-70 (2012) @No $ @ @ Zhong X.Y., Yu J.H., Zhang W.G., Wang Z.D., Dong Q., Tai S., Cui Y.F. and Li H., MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression, Gene., 493(1), 44-51 (2012) @No