International Science Community Association Research Journal of Recent Sciences 15 4 2026 10 2 Embryonic Genome Editing: Scientific Progress and Ethical Boundaries 41 44 EN M Kushalatha 1 Biochemistry department, Maharani Lakshmi Ammanni College for Women Autonomous, Bangalore, India H R Umesh 2 Biochemistry department, Maharani Lakshmi Ammanni College for Women Autonomous, Bangalore, India B S Jyothsna 1 Department of Botany, Government Science College, N.T. Road, Bangalore-01, Karnataka, India S Deepashree Chaitra 2 Department of Botany, Government Science College, N.T. Road, Bangalore-01, Karnataka, India B. Kavitha 1 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India Kumar M. B. Bindu 2 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India G. Priya 3 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India B. Mamatha 4 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India B. Kavitha 1 Department of Microbiology, Nrupathunga University, Bengaluru, India Yadav R. Vijay 2 Department of Microbiology, Nrupathunga University, Bengaluru, India A. Ankitha 3 Department of Microbiology, Nrupathunga University, Bengaluru, India Kalala José Kalala 1 Laboratory of Electrical Engineering and Electronic, Polytechnic Superior National School, Marien Ngouabi University, Brazzaville, Congo Mobonda Flory Lidinga 2 Laboratory of Electrical Engineering, ISTA-Kinshasa, Democratic Republic of the Congo, DR Congo Kazadi André Bandekela 3 Laboratory of Electrical Engineering, ISTA-Kinshasa, Democratic Republic of the Congo, DR Congo Nsongo Timothée 4 Faculty of Sciences and Techniques, Marien Ngouabi University, Brazzaville, Congo Shivendra Tiwari 1 IES, IPS Academy, Indore, MP, India Sanjay Jain 2 UEC, Ujjain, Indore, MP, India Rajendra Sharma 3 UEC, Ujjain, Indore, MP, India Nisha Patidar 1 Department of Engineering Science and Humanities, Chameli Devi Group of Institutions Umikheda, Khandwa Road, Indore, India Nitish Kumar Gupta 2 Department of Applied Chemistry, Shri Govindram Seksaria Institute of Technology and Science, 23 Park Road, Indore, India Harshitha V 1 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, India Sarina P Khabade 2 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, India > Review Paper 2026 4 14 2026 10 2 The appearance of the precise gene-editing tool, unveiled by the development of the technology known as CRISPR-Cas9, has allowed the creation of new remedial strategies for genetically caused conditions analogous to sickle cell anemia and cystic fibrosis. Nevertheless, germline editing, having an impact on future generations, stays a contentious issue. This review aims to critically assess the scientific foundations for editing the genome in embryos, the operations of this procedure, as well as ethical dilemma that surfaced after a procedure was conducted by He Jiankui in 2018 in which he edited mortal embryos without proper regulation. Current technical issues, analogous to out-target and mosaicism and nonsupervisory programs in different countries, are mooted. Although the use of Host Directed Therapy in remedy for rare heritable conditions is apparently promising, there remain major safety and ethical enterprises. The agreement among the international community is strict regulation of the use of this technology, with clear governance and use for the prevention of complaint rather than enhancement. This review article elaborates on different perspectives from bioethics, regulatory bodies, and public opinion to provide a balanced assessment of the current technology. Copyright@ International Science Community Association