International Science Community Association Research Journal of Recent Sciences 15 3 2026 07 2 Green synthesis of Titanium Dioxide nanoparticles from Capsicum annum extract and its Characterization and Evaluation of antioxidant activity 36 41 EN Sahu Suresh 1 Government Engineering College, Ajmer, Rajasthan, India Kumar Vinod 1 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Aggarwal Akanksha 2 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Kulshershtha Amit 3 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Kumar Manish 4 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Kumar Shanta 5 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Tripathi Raj Kumar 6 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Saini Yashwant Kumar 7 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Gupta Shyam Manohar 8 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Ram Anshu Beulah 1 Department of Biotechnology, Nrupathunga University, Nrupathunga Road, Bangalore, Karnataka 560001, India Kour Gurshish 2 Clinical Microbiology Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180 001, India P. Priya 1 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India P.R. Druthi 2 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India M. Jeevitha 3 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India Kabhade Sarina P. 4 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India Stella Bhupanapadu Sunkesula Mary 5 Insearch Laboratory, Bengaluru, Karnataka, India M. Jeevitha 1 Department of Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India P.R. Druthi 2 Department of Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India P. Priya 3 Department of Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India Kabhade Sarina P 4 Department of Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India Stella Bhupanapadu Sunkesula Mary 5 Insearch Laboratory, Bengaluru, Karnataka, India > Research Paper 2026 4 13 2026 07 2 The green synthesis approach for producing nanoparticles has significantly increased due to their adaptable and flexible nature. Titanium dioxide nanoparticles (TiO₂ NPs) were synthesised using Capsicum annuum extract through an eco-friendly green synthesis approach. Plant-derived phytochemicals acted as natural reducing and stabilising agents, enhancing nanoparticle bioactivity. The antioxidant potential of the synthesized TiO₂ nanoparticles was evaluated using DPPH, Ferrozine, and FRAP assays. The nanoparticles exhibited significant free-radical scavenging activity with a clear dose-dependent response, strong ferric-reducing capacity, and surface accessible ferrous ion reactivity, indicating functional antioxidant behaviour. Structural and chemical characterisation using UV–Visible spectroscopy and FTIR spectroscopy confirmed formation of nanoparticles and phytochemical functionalization. The results demonstrate that Capsicum annuum-mediated TiO₂ nanoparticles are structurally stable, functionally active, and biologically relevant, highlighting their potential for biomedical and pharmaceutical applications involving oxidative stress modulation. Copyright@ International Science Community Association