International Science Community Association Research Journal of Recent Sciences 15 3 2026 07 2 QSPR Study of Anti-Hepatitis Drugs using Degree-Based Topological Indices 72 82 EN Sahu Suresh 1 Government Engineering College, Ajmer, Rajasthan, India Kumar Vinod 1 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Aggarwal Akanksha 2 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Kulshershtha Amit 3 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Kumar Manish 4 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Kumar Shanta 5 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Tripathi Raj Kumar 6 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Saini Yashwant Kumar 7 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Gupta Shyam Manohar 8 NTPC Energy Technology Research Alliance (NETRA), Plot No. E-3, Ecotech-II, Udyog Vihar, Greater Noida -201306, Uttar Pradesh, India Ram Anshu Beulah 1 Department of Biotechnology, Nrupathunga University, Nrupathunga Road, Bangalore, Karnataka 560001, India Kour Gurshish 2 Clinical Microbiology Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180 001, India P. Priya 1 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India P.R. Druthi 2 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India M. Jeevitha 3 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India Kabhade Sarina P. 4 Department of PG studies in Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India Stella Bhupanapadu Sunkesula Mary 5 Insearch Laboratory, Bengaluru, Karnataka, India M. Jeevitha 1 Department of Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India P.R. Druthi 2 Department of Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India P. Priya 3 Department of Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India Kabhade Sarina P 4 Department of Biotechnology, Nrupathunga University, Bengaluru, Karnataka, India Stella Bhupanapadu Sunkesula Mary 5 Insearch Laboratory, Bengaluru, Karnataka, India P. Rajeshwari 1 Government Science College, Chitradurga, Karnataka, India Raveesha K.A. 2 Life Sciences, JSS Academy of Higher Education and Research (JSSAHER) Mysuru, Karnataka, India B. Kavitha 1 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India Shetty Chandana R 2 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India R. Pavithra 3 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India V. Vanaja 4 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India Varshini Vidhya 5 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India N. Anuroopa 1 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India R. Prajwal 2 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India M. Kishore Rao 3 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India C. Deepika 4 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India M. Jayashree 5 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India P. Rashmi 6 Department of Microbiology, Nrupathunga University, Bengaluru, Karnataka, India N. Hithyshi 1 Department of Post-Graduate Studies in Zoology, Nrupathunga University, Bengaluru, India B.C. Shashikanth 2 Department of Post-Graduate Studies in Zoology, Nrupathunga University, Bengaluru, India D.A. Uday Kumar 3 Department of Post-Graduate Studies in Zoology, Nrupathunga University, Bengaluru, India H.M. Mohan Kumar 4 Department of Post-Graduate Studies in Zoology, Nrupathunga University, Bengaluru, India S. Priya 1 Department of Computer Science, Government First Grade College, Domlur Shanthi Nagar, Bengaluru, India Urs Bharathi Shettahalli Nagaraje 1 Department of Mathematics, Government Science College, Chitradurga, Karnataka, India > Research Paper 2026 4 15 2026 07 2 Topological indices provide an effective approach to relate molecular structure with the physicochemical properties of pharmaceutical compounds. In this study, selected anti-hepatitis drugs are modelled as molecular graphs, where atoms and bonds are characterized as vertices and edges, respectively. Anti-hepatitis drugs are widely used in the treatment and management of viral hepatitis, and understanding their structural behaviour is important for predicting their physicochemical characteristics. Five degree-based topological descriptors are computed and utilized for quantitative structure–property relationship (QSPR) analysis. The correlations between these indices and selected physicochemical properties, including boiling point (BP), surface tension (ST), index of refraction (IR), molar refractivity (MR), and polar surface area (PSA), are examined. The results indicate that three of the five descriptors exhibit strong positive correlations with BP, MR, and PSA, whereas the remaining two descriptors show comparatively weaker relationships with these physicochemical properties. These findings demonstrate the effectiveness of selected topological descriptors in predicting physicochemical behavior and highlight the applicability of graph-theoretical methods in pharmaceutical research. Copyright@ International Science Community Association