Research Journal of Recent Sciences ________________________________________________ ISSN 2277 - 2502
Vol. 1(ISC-2011), 341-344 (2012)
Res.J.Recent.Sci.

Short Communication

A Study of Transition Metal Complex of Diuretic Drug and study of its
Physico-chemical properties as Potential Therapeutic Agent
Nair Smita
Prestige Institute of Engineering and Science, Indore, M.P. INDIA

Available online at: www.isca.in
(Received 30th December 2011, revised 1st January 2012, accepted 24th January 2012)

Abstract
It has been found that biologically active compounds become more effective and bacterio-static upon chelation with metal ions1.
The biological activity of many drugs has been shown to be enhanced on complexing with metal ions, hence promoting their use in
Pharmacology5. The pharmaceutical action of such ‘drug complexes’ are henceforth studied. In the context of present research
work, drugs are used as ligands or chelating agents that contain atoms or groups like N, O, P etc that can attach with metals or
metal ions by coordinate linkages to form complexes. . Although a large number of therapeutic agents are known, the literature
survey reveals that very little work has been done on the metal complexes of diuretic drugs. The present work deals with the
synthesis of metal complexes derived from diuretic drugs and their physio-chemical analysis to find out ligand- metal ratio of these
complexes in solution. The complexes of Mn salts are prepared. For the structure elucidation of these complexes “Monovariation
method” has been used to ascertain the ligand-metal ratio in the complex. The stability constant of the formed complex was
calculated by molar conductance measurement using Modified Job’s method. The analysis has been carried out using
conductometry and pHmetry. To confirm metal-ligand ratio, conductometric titrations were carried out at room temperature using
analytical grade metal salts. Titrations were carried out with “systronics conductivity-meter” using dip type conductivity cell
having cell constant 1 at room temperature. These findings might be useful in the optimization of Amyloride as lead for future
development of diuretic drugs for hypertension.
Keywords: Diuretic drugs, transition metals, complexes, ligand, conductometry.

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