Research Journal of Recent Sciences ________________________________________________ ISSN 2277 - 2502
Vol. 1(ISC-2011), 275-280 (2012)
Res.J.Recent.Sci.

Emergence of multi-drug-resistant Klebsiella pneumoniae in Neonatal
Intensive Care Units: concern about antimicrobial policies
Shah Manisha N. and Desai Pratibha B
Department of Microbiology, Shree Ramakrishna Institute of Computer Education and Applied Sciences, M.T.B. college campus, Athwalines,
Surat-395 001, Gujarat, INDIA

Available online at: www.isca.in
(Received 29th October 2011, revised 1st January 2012, accepted 5th March 2012)

Abstract
Antimicrobial abuse is a serious risk factor for the emergence of multi-drug-resistant (MDR) pathogens. Multidrug resistant
(MDR) Klebsiella pneumoniae is an increasing cause of neonatal infections in India and in other developing countries.
Objective of this study was designed to monitor temporal change in prevalence of K. pneumoniae as a causative organism for
neonatal infections and its antimicrobial sensitivity pattern. Neonatal infections are clinical syndromes characterized by signs
and symptoms of infections in the first month of life. 550 blood cultures were studied from suspected babies and the
prevalence of K. pneumoniae among them was checked with its antimicrobial susceptibility and case fatality rate at
Department of Microbiology, SRICEAS, Surat, Gujarat. Among 550 suspected neonates in the study period, positivity was
found in 110 cases. Among them, 23 cases were found due to Klebsiella pneumoniae infections, 60.86% of them were fatal.
High degree of resistance to many antibiotics can be seen(%). Most of our strains were shown their resistance to most of the
third generation of cephalosporins used. The incidence of neonatal infections due to K. pneumoniae was higher. All spp. of
K. pneumoniae found as M.D.R., which was in co relevance with the mortality caused by them which knocking and shocking
data, indicating the emergence to check on the cruelty use of antimicrobials in NICUs.
Key words: Multi drug resistant, neonatal infections, klebsiella pneumoniae, case Fatality

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