International Science Community Association Research Journal of Recent Sciences 2277 - 2502 1 6 2012 June 2 The Effects of Induced Hyperthyroidism on Plasma FSH and LH Concentrations in Female of Wistar Rats 55 57 EN Mostafa M.Rady 1 Agricultural Botany Department, Faculty of Agriculture, Fayoum University, 63514-Fayoum, EGYPT Water Relations and Field Irrigation Dept. National Research Centre, Cairo, 12622 EGYPT MaybelleS. Gaballah 2 Murthy B.R.N. 1 Department of Mechanical and Manufacturing Engineering, Manipal Institute of Technology, Manipal 576 104, Karnataka, INDIA Lewlyn L.R.Rodrigues 2 Anjaiah Devineni 3 Ipatova V.M. 1 Moscow Institute of Physics and Technology, Dolgoprudny 141700, RUSSIA Singh Shachi 1 Center for Biotechnology, Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, INDIA Agbo G.A. 1 Faculty of Physical Sciences, Industrial Physics Department, Ebonyi State University, Abakaliki, Ebonyi State, NIGERIA Ibeh G.F. 2 Ekpe J.E. 3 Magarajan U. 1 School of Mechanical and Building Sciences, VIT University, Vellore– 632 014, Tamil Nadu, INDIA Thundilkaruppa RajR. 2 Elango T. 3 Khani Hamid 1 Sama Technical and Vocational Training College, Islamic Azad University, Qaemshahr Branch, Qaemshahr, IRAN YazdaniQanbar Ali 2 Department of Accounting, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IRAN Nasiripour A. 1 Department of Health Services Administration, Science and Research Branch, Islamic Azad University, Tehran, IRAN Afshar KazemiM. 2 Department of Industrial Management, Tehran markaz Branch, Islamic Azad University, Tehran, IRAN Izadi A. 3 Department of Health Services Administration, Science and Research Branch, Islamic Azad University, Tehran, IRAN Idris M.A. 1 Idris O.F. and Sabahelkhier M.K.Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Dongola, SUDAN O.F. Idris 2 Department of Biochemistry and Molecular Biology, Faculty of Science and technology EL-Neelain University, SUDAN Sabahelkhier M.K. 3 > Short Communication 2012 2 22 2012 June 2 Thyroxine and triodothyroine are essential for the normal growth, development and functions for normal organs. These hormones regulate the basal metabolic rate (BMR) of all cells and play a critical role in the development of several organ systems such as reproduction system. Our objectives are to investigate the effects of experimental induced hyperthyroidism on plasma FSH and LHconcentrations in female Wistar rats and answer specific question what was worse to have excess thyroid hormones. The experimental study was located at the University of Kwa-Zulu Natal (UKZN), Faculty of Science and Agriculture, School of Biochemistry, Genetics and Microbiology, Westville Campus South Africa, from October 2009 - May 2010. Twenty four adults female Wistar rats divided into two main groups, twelve rats in each were used. Thyroxine was administered orally. The dose was 100 g/ kg body weights for three weeks daily at 9:00 am; Euthyroid rats received three ml of deionizer water. The results of thyroid hormones concentration (TSH, T and T4) and gonadtrophins (FSH and LH) were determined by using enzyme immunoassay kits from TOSOH, Corporation Japan. By Hitachi 906 analyzer. Rats body weight and food, water consumption were record every third day of experimental. The results of rats body weight showed significant decreased (P o.o5) in hyperthyroid rats compared to control group. Thyroid hormones showed significant (P o.o5) increased in hyperthyroid, but FSH and LH showed conflict results. Copyright@ International Science Community Association