International Science Community Association Research Journal of Recent Sciences 2277 - 2502 1 6 2012 June 2 Antimitotic activity of a New Compound Isolated from the Flower of Prosopis juliflora 22 26 EN Mostafa M.Rady 1 Agricultural Botany Department, Faculty of Agriculture, Fayoum University, 63514-Fayoum, EGYPT Water Relations and Field Irrigation Dept. National Research Centre, Cairo, 12622 EGYPT MaybelleS. Gaballah 2 Murthy B.R.N. 1 Department of Mechanical and Manufacturing Engineering, Manipal Institute of Technology, Manipal 576 104, Karnataka, INDIA Lewlyn L.R.Rodrigues 2 Anjaiah Devineni 3 Ipatova V.M. 1 Moscow Institute of Physics and Technology, Dolgoprudny 141700, RUSSIA Singh Shachi 1 Center for Biotechnology, Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, INDIA > Research Paper 2012 3 22 2012 June 2 A new compound was isolated from the flower of Prosopis juliflora and identified by mass, IR and NMR techniques. Its antimitotic activity was evaluated with the help of allium test. Onion root tips were subjected with 4 and 8 mg/ml concentrations of the compound, up to 48 hours for studying its effect on root mitosis. The roots were examined in permanent root tip squash preparations stained by the aceto-carmine. The results obtained confirmed that the compound have various effects on chromosomes and induced different mitotic abnormalities and structural aberration of chromosomes. Various chromosomal aberrations such as clumping and stickiness, fragmentation, C-mitotic effect, anaphase bridge were observed, which clearly showed the clastogenic, antimitotic and cytotoxic effect. Copyright@ International Science Community Association