International Science Community Association Research Journal of Recent Sciences 2277 - 2502 1 4 2012 April 2 In-Silico Structure Determination of Protein Falstatin from Malaria Parasite Plasmodium Falciparum 68 71 EN Pascal C. 1 Laboratoire d’Etude et de Recherche en Chimie Appiquée (LERCA), Ecoe Poytechnique d'Abomey-Calavi (EPAC), Universit� d'Abomey-Calavi (UAC), 01 BP 2009 Cotonou, REPUBLIC OF BENIN Agbangnan D. 2 Institut Pluridisciplinaire de Recherche sur l�Environnement et les Mat�riaux (IPREM), Universit� de Pau et des Pays de l�Adour (UPPA), UMR 5254 Technopole H�lioparc, 2 avenue du pr�sident d�Angot 64053 PAU Cedex, FRANCE Christine Tachon 3 Institut des Sciences Mol�culaires (ISM), Universit� de Bordeaux 1, CNRS UMR 5255 Batiment A12, 351 cours de la lib�ration, 33405TALENCE cedex, FRANCE Justine Dangou 4 Anna Chrostowska 5 Fouquet Eric 6 DominiqueC.K. Sohounhloue 7 Srivastava K.P. 1 Ganga Singh College, Jai Prakash University, Chapra-841 301, Bihar, INDIA Singh VikashKumar 2 Balamuralitharan S. 1 Department of Mathematics, Sri Ramanujar Engineering College, Chennai-48, INDIA Rajasekaran S. 2 Professor and COE, Department of Mathematics, BS Abdur Rahman University, Chennai-48, INDIA Nwajei G.E. 1 Dept. of Chemistry, Delta State University Abraka, NIGERIA Okwagi P. 2 Dept. of Chemistry, College of Education Agbor, NIGERIA Nwajei R.I. 3 Dept. of Botany, Delta State University, Abraka, NIGERIA Obi-Iyeke G.E. 4 Yousefi Z 1 Department of Civil Engineering, Tabriz Branch, Islamic Azad University, Tabriz, IRAN VefaAkpinar M. 2 Civil Engineering Department, Karadeniz Technical University, Trabzon, TURKEY AntonyRavindran A. 1 Manonmaniam Sundaranar University, Dept. of Geology, Geophysical Research Lab, V.O. Chidambaram College, Thoothukudi, INDIA PebamNganthoiba Mangang 1 School of Social Work, Tata Institute of Social Sciences, Mumbai-400088, INDIA Abbasian S. 1 Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, IRAN Attarzadeh S.R. 2 Faculty of Physical Education and Sport Sciences, Shahid Montazeri University of Mashhad, Mashhad, IRAN Darzabi T. 3 Momeni M. 4 Dev Nikhil 1 YMCA University of Science and Technology, Faridabad, Haryana, INDIA Attri Rajesh 2 Gateway Institute of Engineering and Technology, Sonipat, Haryana, INDIA Mittal Vijay 3 University Institute of Engineering and Technology, M.D. University Rohtak, Haryana, INDIA Kumar Sandeep 4 Mohit 5 Satyapal 6 Kumar Pardeep 7 Motegaonkar ManoramaB. 1 Azad College Ausa, MS, INDIA SalunkeShridar D. 2 Rajarshi Shahu College, Latur, MS, INDIA Amanchi NageswaraRao 1 Protozoology and Environmental Toxicology Unit, Department of Zoology Nizam College, Osmania University, Hyderabad, INDIA Mohd.Masood Hussain 2 Bhatt TarunKumar 1 Department of Biotechnology, Central University of Rajasthan, Kishangarh, INDIA > Short Communication 2012 3 6 2012 April 2 Malaria is the major cause of socio-economic loss to most of the developing countries. Several drugs have been developed against the deadly malaria causing protozoan, Plasmodium falciparum. However, development of drug resistance against existing drugs has necessitated the identification of new drug targets. Several proteases have been identified from malaria parasite which is involved in various processes like haemoglobin degradation, egress of merozoite etc. But more important aspect of malaria biology is the regulation of these proteases for effective regulation of parasite life cycle. Falstatin is such a protein which binds to many cysteine proteases and regulates their activities. Therefore, Falstatin is the potential target for drug discovery. In this study, we determined the three-dimensional structure of Falstatin by molecular modelling using Swiss Modeller and Sali’s Modeller. Ramachandran plot was used for structure validation. Falstatin active site was determined using CastP. Structural analysis of Plasmodium Falciparum Falstatin (Pf-Falstatin) could be instrumental in identifying new drug like molecules. Copyright@ International Science Community Association