International Science Community Association Research Journal of Recent Sciences 2277 - 2502 1 12 2012 December 2 In-vitro Acetylcholine Esterase Inhibition activity of Chalcones with Phenothiazine Moiety 40 43 EN Mohamadian Zahra 1 Department of Computer engineering, Shahrood Branch, Islamic Azad University, Shahrood, IRAN M. Bharani 1 Department of Textile - Fashion Technology, Bannari Amman Institute of Technology, Sathyamangalam, Erode District, TN, INDIA Gowda R.V.Mahendra 2 VSB College of Engineering, Karur, Tamil Nadu, INDIA AdaneAlemmebrat Kiflu 1 Department of Physical Education-Andhra University (AU), Visakhapatnam, INDIA Reddy R.C. 2 SyamBabu M. 3 Mohammed M.B. 1 Department of Applied Science, College of Science and Technology, Kaduna Polytechnic, Kaduna, NIGERIA Mohammed S.S. 2 Adewumi A.A.J. 3 Farshidfar Ramin 1 Sama Technical and Vocational Training College, Islamic Azad University, Qaemshahr Branch, Qaemshahr, IRAN Abbasali Ranjbar 2 Department of Architecture, Sari Branch, Islamic Azad University, Sari, IRAN Srinivas Mondam. 1 Lecturer, Department of Physiotherapy, Windfield International College, Kuala Lumpur, MALAYSIA SrikanthBabu V. 2 Lecturer, Department of Anatomy, MSU, Kuala Lumpur, MALAYSIA KumarB. Raviendra 3 Jalaja Prakash 4 N. Mayavan 1 Department of Futures Studies Madurai Kamaraj University, Madurai, INDIA Sundaram A. 2 VelusamySaranya Akilanpuram 1 Department of Chemistry, Karpagam University, Coimbatore-21, Tamil Nadu, INDIA Subban Ravi 2 > Research Paper 2012 10 10 2012 December 2 A series of chalcones (3a-g) were synthesized by Claisen-Schmidt condensation between 2-acetyl phenothizine (1) and aromatic aldehydes (2a-g). All the synthesized chalcones were characterized by their spectral data (UV, IR, H-NMR, 13C-NMR, MS and elemental analyses). Acetylcholine esterase inhibition activity was carried out for all the synthesized chalcones which showed an IC50 value between 1.0 to 6.4µg/ml and indicated a comparable inhibitory potency, when compared to the control neostigmine with IC50 value of 8.3µg/ml. Copyright@ International Science Community Association