International Science Community Association Research Journal of Recent Sciences 2277 - 2502 1 1 2012 January 2 Significance of Blood Cellular lxr-a Gene Aberration in Coronary Heart Disease Subjects 69 72 EN Gwal A.K. 1 Space Science Laboratory, Department of Physics Barkatullah University Bhopal-462026, INDIA Jain SantoshKumar 2 Panda Gopal 3 Gujar Y.S. 4 Raghuwanshi S. 5 S.K. Vijay 6 Bora Abhijit 1 Tezpur University, Napaam, Sonitpur district, Assam, INDIA Parikh AnkitaN. 1 Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Varodara.390 002, Gujarat, INDIA Mankodi P.C. 2 SenthilKumar A.P. 1 Department of Mechanical Engineering PSG College of Technology, Coimbatore, INDIA Karthikeyan P. 2 Department of Automobile Engineering PSG College of Technology, Coimbatore, INDIA V. PrabhuRaja 3 M. Ramu 4 Somasundharam S. 5 Vasudevan V. 6 Selvakumar B. 1 Department of Mechanical Engineering PSG College of Technology, Coimbatore, INDIA V. PrabhuRaja 2 Department of Automobile Engineering PSG College of Technology, Coimbatore, INDIA R. NandhaKumar 3 SenthilKumar A.P. 4 M.S. Vignesh 5 G.R. VivekSharma 6 Karthikeyan P. 7 Kumar Pradeep 1 Department of Physics, K G K (P G) College, Moradabad 244 001, Uttar Pradesh, INDIA Singh Bhupendra 2 Department of Physics, Hindu College, Moradabad 244 001, Uttar Pradesh, INDIA Kumar Anil 3 Ezenwa I.A. 1 Department of Industrial Physics, Anambra State University Uli, NIGERIA Patil M.M. 1 Dept. of Processing and food Eng., College of Technology and Eng. Maharana Pratap Uni. of Agriculture and Tech. Udaipur, INDIA Kalse S.B. 2 Jain S.K. 3 Pathak Sunil 1 Swami Vivekanand College of Engineering Indore, MP, INDIA Hashemi SeyedAhmadReza 1 South of Iran aquaculture fishery research center, Ahwaz, IRAN Gholamreza Eskandary 2 Hoshang Ansary 3 Dave V.P. 1 Dept. of Experimental Medicine and Biotechnology, P. G. Institute of Medical Education and Research, Chandigarh, INDIA Kaul D. 2 Dept. of Cardiology, P. G. Institute of Medical Education and Research, Chandigarh, INDIA Sharma Y.P. 3 > Short Communication 2011 9 22 2012 January 2 Keeping in view our previous finding that unambiguously revealed a significant positive correlation between the expression of mutated Liver X Receptor (LXR)- gene and the extent of coronary heart disease (CHD), the present study was addressed to explore whether or not this observed blood cellular LXR- gene aberration is pathognomonic feature of CHD. To detect previously reported blood cellular LXR- gene aberration restriction digestion was performed with TaaI endonuclease in the LXR- ligand binding domain derived from the cDNA library of peripheral blood mononuclear cells isolated from different unrelated inflammatory disease group (Rheumatic heart disease, Diabetes, Psoriasis and Tuberculosis ) including coronary heart disease. Inheritance of reported blood cellular LXR- gene aberration was also checked in a family having a higher risk of CHD.Results of our study revealed that LXR- gene aberration was not only selectively and specifically observed in the blood mononuclear cells derived from CHD patients but also showed a nonmendelian epigenetic inheritance in a family having higher risk of CHD. Based upon these results we propose that blood cellular LXR- gene aberration may have the potential to act as a noninvasive marker for the early diagnosis of subjects that are at high risk of development of CHD. Copyright@ International Science Community Association