International Science Community Association Research Journal of Chemical Sciences 2231-606X 9 3 2019 07 18 Octahedral platinum (IV) complexes of mixed piperaquine, sulfadoxine and pyrimethamine: synthesis, spectroscopy, antioxidant and antibacterial studies 24 39 EN Iwuozor Kingsley Ogemdi 1 Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria Ekpunobi Emmanuel Chidubem 2 Department of Microbiology, Abia State University, Uturu, Nigeria Emuobosa Gold 3 Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria Beckley Ikhajiagbe 1 Environmental Biotechnology and Sustainability Research Group, Department of Plant Biology and Biotechnology, University of Benin, Nigeria Kadesh Ignatius Osayamen 2 Environmental Biotechnology and Sustainability Research Group, Department of Plant Biology and Biotechnology, University of Benin, Nigeria Ohanmu E.O. 1 Department of Biological Sciences, Edo University Iyamho, Nigeria and Environmental Biotech and Sustainability Research Group, Dept of Plant Biology and Biotech, University of Benin, Nigeria Ikhajiagbe B. 2 Environmental Biotech and Sustainability Research Group, Dept of Plant Biology and Biotech, University of Benin, Nigeria Anoliefo G.O.2 3 Environmental Biotech and Sustainability Research Group, Dept of Plant Biology and Biotech, University of Benin, Nigeria Ayipo Yusuf Oloruntoyin 1 Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Nigeria Osunniran Wahab Adesina 2 Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Nigeria Obaleye Joshua Ayoola 3 Department of Chemistry, University of Ilorin, Ilorin, Nigeria Badeggi Umar Muhammad 4 Department of Chemistry, Cape Pennisula University of Technology, Cape Town, South Africa Ayinde Monsurat Olabisi 5 Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Nigeria > Research Paper 2019 2 28 2019 07 18 Synthesis of coordination compounds of Pt (IV) with mixed piperaquine-sulfadoxine and piperaquine-pyrimethamine has been carried out by 1:1:1 stochiometry ratio of ligands to metal ion. Characterization of the synthesized complexes was carried out using solubility evaluation, determination of melting point, elemental analysis, UV-visible spectrophotometry, FTIR, 1H NMR, 13C NMR, DEPT-135 and XRD spectroscopy. FTIR spectral data suggest that all the ligands behaved as bidendate ligands with pyrimethamine coordinates to the metal centre through (N-H) and (C-Cl); sulfadoxine through (N-H) and (S=O); piperaquine through (N-H) and (C-Cl). The electronic spectra also revealed that the metal center moiety is six-coordinate with octahedral geometry. The XRD data obtained established the crystal profile and novelty of the metal complexes synthesized. Antioxidant studies carried out using DPPH with ascorbic acid as standard shows metal complexes to be promising antioxidant agents with the IC50 values of 543, 1031. In vitro antibacterial screening of the ligands and synthesized metal complexes were evaluated against Escherichia coli, Staphylococcus aureus and Bacteria anthrancitis using agar diffusion technique. The results obtained reveal that synthesized metal complexes showed enhanced antibacterial activities when compared to the parent ligands and compete well with oxytetracyclin, a renowned antibiotic. Copyright@ International Science Community Association