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Octahedral platinum (IV) complexes of mixed piperaquine, sulfadoxine and pyrimethamine: synthesis, spectroscopy, antioxidant and antibacterial studies

Author Affiliations

  • 1Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Nigeria
  • 2Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Nigeria
  • 3Department of Chemistry, University of Ilorin, Ilorin, Nigeria
  • 4Department of Chemistry, Cape Pennisula University of Technology, Cape Town, South Africa
  • 5Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Nigeria

Res.J.chem.sci., Volume 9, Issue (3), Pages 24-39, July,18 (2019)


Synthesis of coordination compounds of Pt (IV) with mixed piperaquine-sulfadoxine and piperaquine-pyrimethamine has been carried out by 1:1:1 stochiometry ratio of ligands to metal ion. Characterization of the synthesized complexes was carried out using solubility evaluation, determination of melting point, elemental analysis, UV-visible spectrophotometry, FTIR, 1H NMR, 13C NMR, DEPT-135 and XRD spectroscopy. FTIR spectral data suggest that all the ligands behaved as bidendate ligands with pyrimethamine coordinates to the metal centre through (N-H) and (C-Cl); sulfadoxine through (N-H) and (S=O); piperaquine through (N-H) and (C-Cl). The electronic spectra also revealed that the metal center moiety is six-coordinate with octahedral geometry. The XRD data obtained established the crystal profile and novelty of the metal complexes synthesized. Antioxidant studies carried out using DPPH with ascorbic acid as standard shows metal complexes to be promising antioxidant agents with the IC50 values of 543, 1031. In vitro antibacterial screening of the ligands and synthesized metal complexes were evaluated against Escherichia coli, Staphylococcus aureus and Bacteria anthrancitis using agar diffusion technique. The results obtained reveal that synthesized metal complexes showed enhanced antibacterial activities when compared to the parent ligands and compete well with oxytetracyclin, a renowned antibiotic.


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