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Synthesis, Spectral Characterization and Antibacterial Assay: Co(II) Coordination Compounds of 4-Aminoantipyrine based Macrocyclic Ligands

Author Affiliations

  • 1Department of Chemistry, Osmania University, Hyderabad, Telangana State, India

Res.J.chem.sci., Volume 6, Issue (7), Pages 35-47, July,18 (2016)


A new series of tetra dentate N4 donor macrocyclic Schiff bases L1-L5 were synthesized by condensation reaction between thederivative of 4-aminoantipyrine(L) and a variety of diamines such as 1,4-diamino butane, carbanohydrazide,4H-1,2,4-traizole-3,5-diamine,2-amino benzohydrazide and naphthalene-1,8-diamine respectively. Macrocyclic Schiff base ligands L1-L5 were further treated with cobalt chloride to yield Co(II) complexes(CoL1-CoL5). All these newly prepared ligands and complexes have been characterized with the help of Mass, Infra-Red, 1H & 13C NMR, Electronic spectral, Elemental magnetic, Molar conductance and Thermal studies. Macrocycles and complex compounds were screened to evaluate antibacterial property in opposition to some cultured microbes. Inhibition zones are measured further minimum inhibitory concentrations determined, compared with existing drugs.


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