International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Kinetics and Mechanism of Oxidation of Guaifenesin by Keggin type 12-Tungstocobaltate (III) in Hydrochloric Acid

Author Affiliations

  • 1Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, Maharashtra, India
  • 2Department of Chemistry, Shri Shivaji Mahavidyalaya Barshi, 413411 Maharashtra, India

Res.J.chem.sci., Volume 6, Issue (7), Pages 29-34, July,18 (2016)


The kinetics of oxidation of expectorant drug guaifenesin by 12-tungstocobaltate (III) was studied spectrophotometrically at &


  1. Kozhevinkov I. V. (1995)., Heteropoly Acids and Related Compounds as Catalysts for Fine Chemical Synthesis, Catal., Rev. Sci. Eng., 37(2), 311-352. DOI:10.1080/01614949508007097.
  2. Rhule J. T, Hill C. L and Judd D. A., (1998)., Polyoxometalates in medicine., Chem. Rev., 98,327-357. DOI:10.1021/cr960396q.
  3. Raynaud M, Chermann J. C, Plata F, Jasmin C and Mathe G, (1971)., Inhibitors of the murine leukemia sarcoma group viruses: Silicotungstates., Acad. Sci. Paris, 272,347-348.
  4. Weinstock I. A. (1998)., Homogeneous-phase electron-transfer reactions of polyoxomalates., Chem. Rev., 98,113-170. DOI: 10.1021/cr9703414.
  5. Saha S. K, Ali M. and Banerjee P. (1993)., Electron exchange and transfer reactions of heteropoly oxometalates., Coord. Chem. Rev., 122, 41-62. DOI:10.1016/0010-8545(93)80041-3.
  6. Chester A. W. (1970)., Oxidation of alkyl aromatic hydrocarbons by potassium 12-tungstocobaltate(III)., J. Org. Chem, 35, 1797-1800. DOI: 10.1021/jo00831a017.
  7. Nolan A. L, Burns R. C. and Lawrance G. A. (1998)., Oxidation of [CoIIW12O40]6 to [CoIIIW12O40]5 by peroxomonosulfate in strong and weak acid solutions, an example of zero-order kinetics., J. Chem. Soc. Dalton Trans., 3041-3048, DOI: 10.1039/A804598D.
  8. Mizuno N. and Misono M. (1998)., Heterogeneous Catalysis., Chem. Rev., 98(1), 199-218. DOI: 10.1021/cr960401q.
  9. (2008)., Guaifenesin.,, Retrieved 29-10-2008, john.
  10. Gutierrez, K. (2007)., Pharmacotherapeutics: Clinical Reasoning in Primary Care., Elsevier, ISBN-13: 978-1416032878.
  11. Smith S M, Schroeder K, Fahey T Smith and Susan M. (2008)., Over-the-counter medications for acute cough in children and adults in ambulatory settings., Cochrane Database Syst, Rev., 23(1), DOI: 10.1002/14651858.CD001831.pub3.
  12. Puttaswamy and Anu Sukhdev (2009)., Oxidation of mephenesin and guaifenesin with chloramine-B in hydrochloric acid medium: Design of kinetic model., Indian Journal of Chemistry, 48A, 339-345.
  13. Baker, L. C. W. and Mccutcheon, T. P. (1956)., Heteropoly Salts Containing Cobalt and Hexavalent Tungsten in the Anion., J. Am. Chem. Soc., 78, 4503-4510. DOI: 10.1021/ja01599a001.
  14. Rasmussen, P. G. and Brubaker, C. H., (1964)., The Kinetics of the Electron Exchange between the 12-Tungstocobaltate(II) and the 12-Tungstocobaltate(III) Anions in Aqueous Solution., Inorg. Chem., 3, 977-980. DOI: 10.1021/ic50017a011.
  15. Goyal, B., Prakash, A. and Mehrotra, R. N. (1999)., Kinetics and mechanism of the oxidation of hydroxylamine by 12-tungstocobaltate(III) ion in acetate buffer., Indian J. Chem., 38A, 541-546.
  16. Bhosale B. D and Gokavi G. S, (2002)., Kinetics and mechanism of oxidation of antimony (III) by keggin‐type 12‐tungstocobaltate (III) in aqueous hydrochloric acid medium., Int. J. Chem. Kinetics., 359(1), DOI: 10.1002/kin.10097.
  17. Manu Mehrotra and Raj N. Mehrotra (2008)., Kinetics and mechanism of the oxidation of tris (1,10-phenanthroline)iron(II) by peroxomonosulphate (oxone) ion Polyhedron., 27, 2151-2156, DOI: 10.1016/j.poly.2008.04. 011.
  18. Veeresh T M, Lamani S. D and Nandibewoor S. T. (2009)., Mechanistic and spectroscopic investigations of oxidative degradation of aspirin by aqueous alkaline permanganate., Transition Metal Chemistry, 34, 317-324. DOI 10.1007/s11243-009-9197-9.
  19. Naik P. N. Chimatadar S. A. and Nandibewoor S. T. (2009)., Kinetics and oxidation of fluoroquinoline antibacterial agent, norfloxacin, by alkaline permanganate: a mechanistic study., Industrial & Engineering Chemistry Research, 48 (5), 2548-2555. DOI: 10.1021/ie801633t.
  20. Hiremath G. C., Mulla, R. M. and Nandibewoor, S. T. (2005)., Mechanistic study of the oxidation of isonicotinate ion by diperiodatocuprate(III) in aqueous alkaline medium., J. Chem. Res., 5, 197-201, DOI: http://dx.doi. org/10.3184/0308234054213690.
  21. Mahadevaiah D. T. (2006)., Kinetic studies on free radical polymerization of acrylonitrile, initiated by chloramine-T/hydrogen peroxide redox system., J. Appl. Polym. Sci., 102, 5877-5883. DOI: 10.1002/app.24992.
  22. Veeresh seregar, Veeresh T M and Nandibewoor S T (2007)., Ruthenum (III) catalysed oxidation of l-leucine by a new oxidant, diperiodatoargentate(III) in aqueous alkaline medium, polyhedron., 26, 1731-1739, DOI: 10.1016/j.poly.2006.12.021.
  23. Ali M., Saha S. K. and Banarjee, P. (1990)., Kinetics of Electron Transfer between Dodecatungstocobaltate(III) and Thiosulfate in Weak Acidic Medium., Indian J. Chem Sect A, 29, 528.
  24. Amjad Z., Brodovitch J. C. and Auley, A. M., (1977)., Metal-ion oxidations in solution. Part XXI. Kinetics and mechanism of the reaction of ascorbic acid, hydroquinone, and catechol with 12-tungstocobaltoate(III)., Can. J. Chem., 55, 3581-3586. DOI: 10.1139/v77-502.