International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 6 3 2016 March 18 Synthesis and Characterization of 2H-3(o-nitrophenyl)-3,4-dihydro-Chloro-1,3-benzoxazine studies of Antimicrobial and Antifungal activity 25 31 EN UDO Itoro Esiet 1 Department of Chemistry, University of Uyo, Uyo, Akwa Ibom State, Nigeria Gloria Obuzor 2 Department of Pure and Industrial Chemistry, University of Port Harcourt, Nigeria Michael Horsfall Jnr 3 Department of Pure and Industrial Chemistry, University of Port Harcourt, Nigeria Zia-ul Haq 1 Institute of Chemical Sciences, Gomal University Dera Ismail Khan 29050, KPK-Pakistan Azim khan khattak 2 Institute of Chemical Sciences, Gomal University Dera Ismail Khan 29050, KPK-Pakistan Farmanulla Khan 3 Institute of Chemical Sciences, Gomal University Dera Ismail Khan 29050, KPK-Pakistan Ali Athar 4 Department of Chemistry, University of Science and Technology Bannu 28100, KPK-Pakistan Shahid ullah khan 5 Department of Physics, University of Science and Technology Kohat 28100, KPK-Pakistan Zahid khan 6 Department of Physics, University of Science and Technology Kohat 28100, KPK-Pakistan K. Tharini 1 PG and Research Department of Chemistry, Govt. Arts College, Tiruchirappalli – 22, TN, India K. Raja 2 PG and Research Department of Chemistry, Govt. Arts College, Tiruchirappalli – 22, TN, India Senthilkumar A.N. 3 PG and Research Department of Chemistry, Alagappa Government Arts College, Karaikudi - 630 003 India Hitesh R Patel 1 Department of Chemistry, M N College, Visnagar, 384315, Gujarat, India Asha D Patel 2 Department of Chemistry, M N College, Visnagar, 384315, Gujarat, India Dilesh Indorkar 1 Department of Chemistry, Dr. H.S. Gour Central University Sagar, GDC Sausar, MP, 470 003, India O.P. Chourasia 2 Department of Chemistry, Dr. H.S. Gour Central University Sagar, GDC Sausar, MP, 470 003, India S.N. Limaye 3 Department of Chemistry, Dr. H.S. Gour Central University Sagar, GDC Sausar, MP, 470 003, India > Research Paper 2016 1 29 2016 March 18 4H-3,1-Benzoxazinone derivatives bear saturated aliphatic substituent’s at key position e.g. CH3, CH2COCH3, CH2CN, C3H7(n) and CH2CH2COOH, have electronically unsaturated character which make their synthesis difficult because their are not satisfactorily stable rings (so called dynamic benzoxazinones) New organic substituent’s with special properties in steric and electronic manner helped to solve this problem. Synthesis and behavior of 2-carboxyvinyl-4H-3,1-Benzoxazinone towards nucleophiles have been reported with the aim of studying the effect of conjugated double bond and the stability of oxazinone ring via the interaction of 3,5-dibromoanthanilic acid viz. maleic anhydride in boiling n-butanol. One of the most important features in 4H-3, 1-Benzoxazinone chemistry is their use as key starting materials for synthesizing new heterocyclic systems with potential biological activity. The present work is in conjugation with our ongoing programe on the utilizing of readily obtainable starting materials for the synthesis of heterocyclic systems. Copyright@ International Science Community Association