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Potent Antimicrobial agents derived from Combination of Transition metal with Sulfa drugs

Author Affiliations

  • 1Department of Chemistry, M N College, Visnagar, 384315, Gujarat, India
  • 2Department of Chemistry, M N College, Visnagar, 384315, Gujarat, India

Res.J.chem.sci., Volume 6, Issue (3), Pages 20-24, March,18 (2016)


In the present study a noval 4-oxo - 4-[{4-(N-(thiazol-2-yl)sulfamoyl) phenyl} amino] butanoic acid (OTSPAB) was prepared by reaction of succinic anhydride with Sulphathiazol. The prepared ligand was exemplified by physical and spectroscopic studies. The transition metal complexes viz. Cu2+, Ni2+ , Co2+, Mn2+ and Zn2+ of OTSPAB were synthesized and characterized by different properties. All the prepared metal complexes and ligand were studies as antimicrobial agent. Among all the metal complexes, Zn2+ and Cu2+ metal complexes have shown significant activity.


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