International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 6 1 2016 January 18 Physico-Chemical and Biological Analysis of N-4-Disubstituted Thiosemicarbazone Ligand and its Transition Metal Complexes 16 21 EN A Ewais Hassan 1 Chemistry Department, Faculty of Science, King Abdulaziz University, P.O Box.80203, Jeddah, 21589, SAUDI ARABIA Abdel-Salam Ahmed H 2 Chemistry Department, Faculty of Science, Alexandria University, Alexandria, EGYPT Ismail Mohamed K 3 Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef City, EGYPT S.B. Dare 1 Department of Chemistry, New Arts Commerce and Science College, Ahmednagar, Maharashatra, INDIA A. Vijayalakshmi 1 Department of Chemistry, RMK Engineering College, Chennai, Tamilnadu, India Balraj Vidyavathy 2 Department of Chemistry, Velammal Engineering College, Chennai, Tamilnadu, India B. Chithra 3 Department of Chemistry, RMK Engineering College, Chennai, Tamilnadu, India V.S. Gavhane 1 Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS, India D.M. Suryawanshi 2 Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS, India A.S. Rajbhoj 3 Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS, India S.T Gaikwad 4 Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS, India > Research Paper 2015 8 30 2016 January 18 The Cr(III), Mn(II), Fe(II) and Ni(II) transition metal complexes of novel (E)-1-(2-hydroxybenzylidene)-4,4diethylthiosemicarbazide have been prepared and characterized by micro anaysis (elemental), spectral (FTIR, 1H-NMR), molar conductivity and X-ray diffraction studies. A molar conductivity measurement shows that, Cr (III) and Fe (II) complex of ligand (HBDT) are electrolytic in nature. FTIR studies suggested the attachment of central metal ion to ligand portion through the imine linkage-nitrogen, thioketonic sulphur and phenolic oxygen. According to spectral studies an octahedral geometry may be assigned for all four complexes. The ligand (HBDT) and its transition metal complexes have also been tested for their antibacterial and antifungal activity against Staphylococcus aureus, Bacillus substilis, Aspergillus niger and Fusarium oxysporium species. All complexes and ligand showed considerable activity compared with standard drug ciprofloxacin. Copyright@ International Science Community Association