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A Novel Bromonaphthyl Based 2-Amino-1,3-Thiazines: Synthesis, Characterization with Invitro Antimicrobial Screening

Author Affiliations

  • 1PG and Research Department of Chemistry, Rajah Serfoji Govt. College, Thanjavur-613 005, Tamilnadu, INDIA

Res.J.chem.sci., Volume 5, Issue (7), Pages 8-11, July,18 (2015)


A clinically important substrate of bromosubstituted acetylnaphthalene was used as the precursor for the preparation of a series of 1-(2-bromonaphthalen-6-yl)-3-phenylprop-2-en-1-ones. The formed unsaturated ketones on treatment with thiourea in the presence of base like KOH in alcohol yields corresponding 4-(2-bromonaphthalen-6-yl)-6-phenyl-6H-1,3-thiazin-2-amine. The synthesized thiazines are evaluated their structure on the basis of NMR, MASS, IR and Elemental analyses along with their physical data. The antibacterial and antifungal activities indicate some of these thiazines are potential antimicrobial agents.


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