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Microwave Assisted Extraction of Analgesic Compounds of the Root of Ximenia americana (Olacaceae)

Author Affiliations

  • 1Laboratory of Chemistry, Faculty of Science, P.O. Box 24157, University of Douala, CAMEROON
  • 2Laboratory of Applied Chemistry, P.O.Box.455 ENSAI Ngaoundéré, CAMEROON
  • 3Laboratory of Biology, Faculty of Science, P.O. Box 24157, University of Douala, CAMEROON

Res.J.chem.sci., Volume 4, Issue (7), Pages 7-10, July,18 (2014)


In the present study, roots of Ximenia Americana were selected on the basic of their phytoconstituents profile and an attempt was made to the use of household microwave for extraction of analgesic compound. The extracts dose of 100, 200, 400 mg/kg body weight were evaluated for analgesic activities using acetic acid induced writhing test and hot plate test in rats. From the results, a longer extraction duration time was observed in soxhlet and maceration than in the microwave extraction by a factor of 240 and 900 respectively. In addition, household microwave extraction showed a much higher extraction rate. The yield obtained by soxhlet extraction method was higher than that of microwave and maceration extraction method, however inhibition of pain by analgesic compounds extracts from microwave assisted extraction method was improved by 9% and 22% with respect to soxhlet and maceration extraction method respectively. Futhermore, Microwave extract also increased the reaction time of the rat on the hot plate by 3sec. and 7sec. compared to soxhlet and maceration extract as well. Finally, household microwave appear to be an alternative extraction technique for fast extraction of analgesic compounds from Ximenia americana in the laboratory scale. It requires shorter time, less solvent, higher extraction rate and better product with better yield.


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