Synthesis, Spectral, Electrochemical analysis and Screening for a- Glucosidase inhibition of some complexes of Cobalt (II) and Ethylenediamine
Author Affiliations
- 1 Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalaya, Chitrakoot, Satna, MP, INDIA
Res.J.chem.sci., Volume 4, Issue (6), Pages 13-17, June,18 (2014)
Abstract
Schiff bases, having amine group and their metal complexes are widely used for industrial purposes and also reveal a wide range of biological applications. This work describes the most promising biological activities. Cobalt metal complexes, the [Co(en)3]2NO3 has most potent inhibitory activity among three complexes, having 784.12 µg/ml IC50 value while [Co(en)3]2Cl shows mild inhibition i.e. 47.39±0.83 %.
References
- Wild S., Roglic K., Green A., Sicree R. and King H., Global prevalence of diabetes, Estimation for the year 2000 and projections for 2030, Diabetes Care, 27, 1047–1053 (2004)
- Eman A. Alam, Initiation of Pharmaceutical Factories depending on more Application of Biotechnology on some Medicinal Plants Review Article (In Vitro Production of some Antioxidant, Analgesic, Antibacterial, Antidiabetic agents), Research Journal of Recent Sciences, 1(ISC-2011),398-404 (2012)
- Thomas H.E, Kay T.W., Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse, Diabetes Metab. Res. Rev.16(4), 251-261 (2000)
- Iwahashi H., Itoh N., Yamagata K., Imagawa A., Nakajima H., Tomita K., Moriwaki M., Waguri M., Yamamoto K., Miyagawa J., Namba M., Hanafusa T., Matsuzawa Y., Molecular mechanisms of pancreatic beta-cell destruction in autoimmune diabetes: potential targets for preventive therapy, Cytokines Cell Mol. Ther.,4(1), 45-51 (1998)
- Leahy J.L., Pathogenesis of type 2 diabetes mellitus, Arch. Med. Res., 36(3), 197-209 (2005)
- Kumari M. and Jain S, Tannins: An Antinutrient with Positive Effect to Manage Diabetes, Research Journal of Recent Sciences, 1(12), 70-73, (2012)
- Kaku K., Pathophysiology of Type 2 Diabetes and Its Treatment Policy, J. M. A. J., 53(1), 41–46 (2010)
- Coulston L., Dandona P., Insulin-like effect of zinc on adipocytes, Diabetes, 29(8), 665-667 (1980)
- Pandeya K.B., Tripathi I.P., Mishra M.K., Dwivedi N., Pardhi Y., Kamal A., Gupta P., Dwivedi N. and Mishra C., A Critical Review on Traditional Herbal Drugs: An Emerging Alternative Drug for Diabetes, I.J.O.C.,3(1), 1-22 (2013)
- Tripathi I.P., Mishra M. K., Kamal A., Mishra C., Tripathi R., Shastri L. K., Pandeya K. B., Synthesis, Characterization of some Antidiabetic Copper Complexes with Ethylenediamine, Res. Jrn. of Chem. Sci.,3(12), 54-59 (2013)
- Beattie J.K., Conformational Analysis of Tris (ethylenediamine) Complexes, Acc. Chem. Res, 253-259 (1971)
- Pistia-Brueggeman G. and Hollingsworth R.I., A preparation and screening strategy for glycosidase inhibitors, Tetrahedron, 57, 8773-8778 (2001)
- Shinde J., Taldone T., Barletta M., Kunaparaju N., Hu B., Kumar S., Placido J., Zito S.W., Alpha-glucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto-Kakizaki (GK) rats, Carbohydr. Res., 343, 1278-1281 (2008)
- http://people.cedarville.edu/student/s1209916/co_en.pdf (2014)
- Talba T., Shui X. W., Cheng Q., Tian X., Antidiabetic effect of glucosaminic acid-cobalt (II ) chelate in streptozotocin-induced diabetes in mice, Diabetes Metabolic Syndrome and Obesity: Targets and Therapy, 137–140 (2011)
- Saker F., Ybarra J., Leahy P., Hanson R.W., Kalhan S.C., Ismail-Beigi F., Glycemia-lowering effect of cobalt chloride in the diabetic rat: role of decreased gluconeogenesis, Am. J. Physiol.,274(6 Pt 1), E984-91 (1998)