International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 4 12 2014 December 18 Aqueous Phase Supramolecular Synthesis of 3′-spirocyclic oxindoles Catalyzed by β-cyclodextrin 21 33 EN Ayub S 1 CivilEngineering Department Z.H. College, Faculty of Engineering and Technology. A.M.U.,Aligarh. INDIA F.Changani Khorasgani 2 Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, IRAN Kumar Rajesh 1 Department of Chemical Engineering, H.B. Technological Institute, Kanpur-208002, INDIA Prasad Ram 2 Indorkar Dilesh 1 Department of Chemistry, Dr. H.S. Gour Central University Sagar, MP, 470 003, INDIA Chourasia O.P. 2 Limaye S.N. 3 Naskar Subhendu 1 Department of Chemistry, Bandwan Polytechnic (under DTET-WB), Purulia, West Bengal, INDIA. Suprakash Roy 2 Department of Chemistry, Raja Ranjit Kishore Government Polytechnic College (under DTET-WB), West Midnapore, West Bengal, INDIA > Research Paper 2014 10 24 2014 December 18 A high yielding green protocol is described for the synthesis of 3-spirocyclic oxindoles by [3+2] cycloaddition reaction of azomethine ylides to the 12 double bond of andrographolide (a natural product isolated from Andrographis paniculata Nees) in water catalyzed by -cyclodextrin. Copyright@ International Science Community Association